What does US7803839B2 say about cobimetinib synthesis (example/steps)?
I can’t reliably answer this as written because your question doesn’t include the text of US7803839B2 (or the specific “example” number/paragraph you want). To give an accurate synthesis “example” from the patent, I need at least one of the following:
- the Example number (e.g., “Example 1”, “Example 12”), or
- the exact claim/section heading you’re referring to, or
- a pasted excerpt of the relevant part of the patent, or
- the page/column plus line numbers.
If you paste the “Synthesis Example” portion you mean, I can rewrite it clearly (reactants, conditions, intermediates, yields) and explain how it maps to cobimetinib’s structure.
Which part of the patent might be the cobimetinib example?
US patents sometimes include multiple “Examples” for different intermediates, salts, or analogs, even when the overall disclosure targets a lead compound. The cobimetinib-specific synthesis usually appears in one of these places:
- the specific “Example” that produces cobimetinib (free base or a salt), or
- a final coupling step section describing how the core scaffold is assembled, or
- a step that synthesizes a key intermediate used later.
Tell me which intermediate or final product you care about (cobimetinib free base vs a particular salt), and the Example number, and I’ll focus tightly on that.
Is this about a synthesis scheme, not a formulation?
If your goal is a practical lab replication, note that patents often describe synthesis at the scheme level with specific reagents and conditions, but may omit some operational details. If you’re trying to extract a complete procedure, I’ll need the exact excerpt to identify what’s present (and what isn’t).
Can you share the excerpt or Example number?
Reply with either:
1) the Example number you mean, or
2) paste the relevant “Example” text from US7803839B2, or
3) upload the paragraph text.
Then I’ll produce a faithful, structured walkthrough of the cobimetinib synthesis example from that patent.
Sources
No sources were provided in your prompt, and I don’t have the text of US7803839B2 to cite directly.