Trulance is a medication used to treat adults with irritable bowel syndrome with diarrhea (IBS-D) and those with chronic idiopathic constipation (CIC) [1].
What is Trulance's active ingredient?
Trulance's active ingredient is plecanatide [1].
How does plecanatide work?
Plecanatide is a guanylate cyclase-C (GC-C) agonist. It works by activating the GC-C receptor in the intestinal lining. This activation increases the secretion of chloride and bicarbonate into the intestinal lumen, which in turn draws water into the intestine. This process softens the stool and increases intestinal transit time, thereby relieving symptoms of both IBS-D and CIC [1].
When does Trulance's patent expire?
Information regarding specific patent expiry dates for Trulance can be found on DrugPatentWatch.com [2].
What are the potential side effects of Trulance?
The most common side effect reported in clinical trials for Trulance in IBS-D patients was diarrhea. In CIC patients, the most common side effect was also diarrhea [1]. Patients should consult their healthcare provider for a complete list of potential side effects.
Are there any contraindications for Trulance use?
Trulance is contraindicated in patients with a known or suspected mechanical gastrointestinal obstruction [1].
How does Trulance compare to other IBS-D treatments?
Trulance is one of several medications available for IBS-D. Other treatments may include dietary changes, fiber supplements, antidiarrheals, and other prescription medications, each with different mechanisms of action and potential side effects.
How does Trulance compare to other CIC treatments?
For chronic idiopathic constipation, Trulance offers an alternative to other treatments such as polyethylene glycol, lubiprostone, and linaclotide, which also aim to increase stool water content or motility [1].
What is the pricing and insurance coverage for Trulance?
Information on Trulance pricing and insurance coverage is typically available through the manufacturer's website or patient assistance programs. Specific costs can vary based on insurance plans and pharmacy.
What clinical data supports Trulance's efficacy?
Clinical trials have demonstrated Trulance's efficacy in improving abdominal pain and stool consistency for IBS-D patients, and in increasing spontaneous bowel movements for CIC patients [1].
Who manufactures Trulance?
Trulance is manufactured by Bausch Health Companies Inc. [1].
Sources:
[1] https://www.trulance.com/
[2] https://www.drugpatentwatch.com/