Based on the available information, there is no explicit contraindication for administering live vaccines immediately after receiving Cosentyx (secukinumab) [1]. However, it is generally recommended to avoid live vaccines during and shortly after immunosuppressive therapy due to the potential reduced effectiveness of the vaccine and the risk of infection [2][3].
Secukinumab, the active ingredient in Cosentyx, is a monoclonal antibody that selectively binds to interleukin-17A, a cytokine involved in the inflammatory response [1]. While secukinumab is not expected to have a significant impact on the immune response to live vaccines, the overall immunosuppressive effect of the drug should be considered [2].
The Centers for Disease Control and Prevention (CDC) recommends that live vaccines be deferred during immunosuppressive therapy and for a period after discontinuation, depending on the specific drug and the patient's immune status [3]. It is essential to consult the prescribing information for Cosentyx and the specific live vaccine for more detailed recommendations [1][2].
In summary, while there is no specific contraindication for administering live vaccines immediately after Cosentyx, it is generally recommended to avoid live vaccines during and shortly after immunosuppressive therapy due to the potential reduced effectiveness of the vaccine and the risk of infection. Always consult the prescribing information for Cosentyx and the specific live vaccine for more detailed recommendations.
Sources:
[1] DrugPatentWatch.com. Cosentyx (secukinumab) - DrugPatentWatch. https://www.drugpatentwatch.com/drugs/cosentyx.
[2] Novartis Pharmaceuticals Corporation. Cosentyx (secukinumab) injection, for subcutaneous use, prescribing information. January 2023. https://www.novartis.us/sites/www.novartis.us/files/cosentyx.pdf.
[3] Centers for Disease Control and Prevention. General Best Practice Guidelines for Immunization: Best Practices Guidance of the Advisory Committee on Immunization Practices (ACIP). Chapter 3: Contraindications and Precautions. Updated February 10, 2022. https://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/contraindications.html.