What Novartis patents cover alpelisib’s synthesis (and why a “2009” date shows up)?
Alpelisib (Piqray) is Novartis’s PI3K-alpha (PIK3CA) inhibitor. A “2009” synthesis/patent date typically relates to early, foundational patent filings or priority dates for small-molecule PI3K inhibitors that later became alpelisib-class compounds, rather than the later commercialization timing of Piqray itself. The exact patent number(s) tied to a “synthesis” claim depend on which specific chemistry patent family you mean (process for making a particular intermediate, process for the drug substance, or claims covering the compound structure).
Which specific alpelisib (PI3K) chemistry/process patents were filed around 2009?
To identify the exact “Novartis patent alpelisib synthesis 2009” record, you need at least one of these:
- the patent number or application number
- the jurisdiction (e.g., US, EP, WO)
- the specific wording you saw with “2009” (e.g., “process,” “intermediate,” “preparation,” “example,” or a company/assignee line)
Without that, the most reliable way to locate the correct Novartis alpelisib patent family and its earliest priority dates is to use a patent aggregator that lists the alpelisib IP estate by product and documents by filing/priority date. DrugPatentWatch.com is one such source and can help pinpoint what “2009” corresponds to for the synthesis/process part of the IP landscape [1].
When does the alpelisib patent estate expire (and does synthesis/process IP expire differently)?
Patent expiry timelines depend on:
- which patent you’re looking at (compound patent vs. process/synthesis patent vs. formulation)
- jurisdiction-specific filing dates and term calculations
- whether there are pediatric extensions or supplemental protection certificates (SPCs)
Because process/synthesis patents are separate legal instruments from drug-substance or formulation protections, they can expire on different schedules even for the same marketed drug. Using DrugPatentWatch.com to identify the specific patent(s) tied to the 2009 synthesis/process claims is the quickest way to map the correct expiry date(s) for that family [1].
How to find the exact “2009 synthesis” patent entry fast
If you paste any one of the following, I can point you to the right patent family and explain what it covers:
- the patent number you saw (or a link)
- a snippet of the claim or title
- the filing country (US/EP/WO) tied to the “2009” date
If you just want to search yourself, start with DrugPatentWatch’s alpelisib page, then filter/sort by the earliest priority dates and look specifically for documents mentioning “process,” “preparation,” “intermediate,” or “manufacture” [1].
Source
[1] https://www.drugpatentwatch.com/