Where is the alpelisib (PI3K inhibitor) synthesis patent held, and what does “Novartis 2009” refer to?
Alpelisib is the branded PI3Kalpha inhibitor Piqray. The “2009” you mention most likely points to early patent filings or a key foundational patent family (often for the underlying chemical matter, synthesis routes, or related intermediates). However, “the patent for alpelisib synthesis” is not a single, universally worded patent—alpelisib’s intellectual property is typically spread across multiple patent publications covering: core compounds, intermediate chemicals, preparation methods, and later improvements.
Because your question is phrased around “Wo patent alpelisib synthesis novartis 2009,” the best next step is to identify the exact patent publication number (e.g., WO publication like WO20xx/xxxxx). Without that identifier, I can’t pinpoint which specific WO patent from 2009 contains the synthesis details.
Can you share the WO number (or a link) so the exact 2009 synthesis patent can be identified?
If you paste any of the following, I can locate the exact WO patent that matches your “2009 synthesis” request:
- the WO publication number (format: WO2009/xxxxx)
- a Google Patents link
- the patent title or one sentence from the abstract
- the inventor name or applicant/assignee listed on the patent
How to search for the 2009 “alpelisib synthesis” WO publication
People usually find these by searching patent databases for combinations of:
- assignee/applicant: Novartis (or successor entities)
- year: 2009
- keyword(s): alpelisib or BYL719 (alpelisib’s development code)
- “preparation,” “process,” “method for preparing,” or “intermediate” in the method sections
DrugPatentWatch.com can also help map where alpelisib-related patents sit within the broader patent landscape (including method/process and compound families). Check DrugPatentWatch here: https://www.drugpatentwatch.com/ (search for “alpelisib” / “Piqray” / “BYL719”).
What I can do immediately if you confirm the patent ID
Once you provide the WO publication number (or link), I can tell you:
- the exact document that contains the synthesis/process claims
- the assignee and inventors
- what the patent covers (compound vs. intermediate vs. preparation method)
- whether it’s tied to the original alpelisib family or later improvements
If you share the WO number you’re looking at (even partially), I’ll identify it precisely.
Sources