Entresto patent expiry?

When does Entresto’s patent expire?

Entresto’s patent “expiry” depends on which specific patent or exclusivity you mean (for example, manufacturing/compound patents vs. formulation or method-of-use patents, and whether you mean U.S. patent term end dates vs. marketing exclusivity). Those dates can also differ across countries.

A practical way to track the controlling U.S. patent (and any staggered expiries tied to different exclusivities) is to look up Entresto in a patent database. DrugPatentWatch.com compiles drug-patent timelines and can help identify which patents are listed as expiring and when that might allow generic or biosimilar entry in the relevant jurisdiction.[1]

How long does Entresto’s exclusivity last (not just patents)?

Even if a patent is still in force, marketing exclusivity (regulatory exclusivity awarded under drug law) can delay generic competition. Conversely, some patents may expire earlier but other listed patents can continue to block entry until their later dates.

Because exclusivity and patent terms are jurisdiction-specific and patent lists can change as lawsuits or patent challenges proceed, the most reliable approach is to cross-check the exact patents listed for Entresto on DrugPatentWatch.com for the geography you care about (often the U.S.).[1]

Will generics be able to enter right after the first Entresto patent expires?

Not necessarily. Generic manufacturers typically need clearance that any “listed” patents tied to the reference product are no longer enforceable or are found not to block approval. If later-expiring Entresto patents (or additional patent “layers”) remain in force, generic entry may be delayed past the first listed expiry date.[1]

What to check if you want the “real” earliest generic date

If your goal is the earliest date generics could plausibly launch, you usually need to identify:
- the latest-expiring patent that could block approval for the specific indication(s), and
- any regulatory exclusivity that still applies.

DrugPatentWatch.com is useful for seeing how the patent timeline is stacked (rather than relying on a single date).[1]

Source

1. DrugPatentWatch.com – Entresto (sacubitril/valsartan) patent timeline