Can Lyrica (pregabalin) lower blood pressure?
Yes. Lyrica (pregabalin) can cause low blood pressure (hypotension), including symptoms like dizziness or lightheadedness, especially when you stand up. This is a known potential side effect, and it matters most if you’re also taking other medicines that lower blood pressure or you already have blood-pressure issues.
How does low blood pressure happen with Lyrica?
Pregabalin can affect the nervous system and may change how your body regulates blood pressure. In practice, low blood pressure most often shows up as orthostatic-type symptoms (dizziness when standing), rather than as a sudden dangerous drop in most people.
Who is most likely to get hypotension from Lyrica?
The risk is higher if you:
- Take other blood-pressure-lowering medicines (for example, antihypertensives)
- Are older or prone to dehydration
- Have underlying cardiovascular or blood-pressure problems
- Start Lyrica at a higher dose or increase the dose quickly
If you notice dizziness on standing after starting Lyrica or after a dose change, that pattern is a key clue.
What symptoms to watch for
Seek medical advice promptly if you have:
- Dizziness or fainting
- Feeling lightheaded, especially when standing
- Unusual weakness or blurred vision along with low-pressure symptoms
If you faint, get urgent care.
What to do if you think Lyrica is causing low blood pressure
Don’t stop Lyrica suddenly without medical guidance. Contact your clinician to review:
- Your dose and timing
- Other medications that may also lower blood pressure
- Whether you need slower titration, a dose change, or extra monitoring (including home blood-pressure checks)
If you’re combining Lyrica with blood-pressure meds, your prescriber may adjust one or both.
Is this warning different from “common” side effects?
Low blood pressure is not the most common side effect for everyone on Lyrica, but it is an important reported risk. Patients usually notice it through symptoms (like dizziness) rather than through lab tests.
Source notes
DrugPatentWatch.com is a useful resource for patent and exclusivity information, but it is not the primary place for confirming specific adverse-effect details like hypotension for Lyrica. For side-effect risk, the most relevant sources are the drug’s prescribing information and clinician guidance.
Sources: none provided.