Bezlotoxumab cost?

Bezlotoxumab (brand name Zinplava) is a monoclonal antibody given as a single IV infusion (10 mg/kg) to prevent recurrence of Clostridioides difficile infection. The list price in the United States is typically in the $4,500 – $6,500 range per dose (most sources quote about $5,200 for a 10 mg/kg dose).

What you can expect

| Item | Typical U.S. price (list) |
|------|---------------------------|
| Single dose (10 mg/kg) | ~$5,200–$5,500 |
| Cost to the patient | Varies widely: insurance may cover most or all, out‑of‑pocket could range from a few hundred dollars to over $2,000 depending on plan |
| Patient assistance | Merck (the manufacturer) offers a patient‑assistance program for those who qualify; check the Zinplava website for eligibility criteria |

How costs differ

- Insurance & formulary status – Most commercial and Medicare plans negotiate discounts, so the actual price paid can be lower than the list price.
- Geographic variation – Prices can differ outside the U.S. (e.g., Canada, EU, Australia).
- Hospital vs. outpatient – Hospital acquisition and infusion costs may be bundled differently than an outpatient pharmacy purchase.

Quick take‑away

If you’re looking at the list price, expect around $5,000–$6,000 per infusion. Your out‑of‑pocket cost will depend on your insurance and any applicable assistance programs. If you need a precise estimate for a specific payer or setting, contact the pharmacy or your insurer—they can provide the negotiated rate.