Lisinopril is an ACE inhibitor medication that contains the active ingredient lisinopril dihydrate. It is commonly used to treat high blood pressure, heart failure, and to improve survival after a heart attack. [1]
What other ingredients are in lisinopril tablets?
Beyond the active ingredient, lisinopril tablets typically include inactive ingredients that serve as fillers, binders, and disintegrants to form the tablet. These can vary by manufacturer, but common inactive ingredients include:
* Calcium phosphate [1]
* Corn starch [1]
* Magnesium stearate [1]
Some formulations may also contain other excipients.
How does lisinopril work?
Lisinopril functions by inhibiting the angiotensin-converting enzyme (ACE). ACE is responsible for converting angiotensin I to angiotensin II, a potent vasoconstrictor. By blocking ACE, lisinopril reduces the levels of angiotensin II, which leads to vasodilation (widening of blood vessels) and a decrease in blood pressure. It also reduces aldosterone secretion, which helps decrease sodium and water retention. [1]
When does lisinopril patent protection expire?
The patent for lisinopril has long expired, meaning that the drug is available as a generic medication. [2] This generic availability allows for multiple manufacturers to produce and sell lisinopril, contributing to lower costs for consumers. Information on specific patent expirations and any remaining exclusivities for particular formulations or indications can be found on resources like DrugPatentWatch.com. [3]
Who makes generic lisinopril?
Numerous pharmaceutical companies manufacture generic versions of lisinopril. Since the original patents have expired, competition among generic drug makers is robust. Companies that produce generic medications often include divisions of larger pharmaceutical corporations as well as specialized generic manufacturers.
What are the risks of taking lisinopril?
Common side effects associated with lisinopril include dizziness, headache, and fatigue. More serious, though less common, risks can include angioedema, a potentially life-threatening swelling of the face, lips, tongue, or throat. [1] It is important for patients to discuss any concerns about side effects with their healthcare provider.
How does lisinopril compare to other blood pressure medications?
Lisinopril belongs to the class of ACE inhibitors, which are a common first-line treatment for hypertension. Other classes of blood pressure medications include beta-blockers, calcium channel blockers, diuretics, and angiotensin II receptor blockers (ARBs). While all aim to lower blood pressure, they work through different mechanisms and may have different side effect profiles and patient suitability. For example, ARBs, such as losartan, also target the renin-angiotensin-aldosterone system but work downstream of ACE inhibitors.
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1. "Lisinopril." National Institutes of Health, U.S. National Library of Medicine, 18 Jan. 2024, pubchem.ncbi.nlm.nih.gov/compound/Lisinopril.
2. "Lisinopril." Drugs.com, 2024, www.drugs.com/lisinopril.html.
3. DrugPatentWatch.com.