Based on the information available, there is no direct evidence to suggest that Lipitor, a medication used to treat high cholesterol, enhances the effectiveness of opioids.

Opioids are a type of drug used to relieve pain, and they work by interacting with opioid receptors in the brain [1]. Lipitor, on the other hand, is a statin medication that lowers cholesterol levels in the blood by reducing the amount of cholesterol produced by the liver [2].

While both Lipitor and opioids can be used to manage pain, they have different mechanisms of action and are typically used to treat different types of pain. Lipitor is not typically used to enhance the effectiveness of opioids or any other pain medication.

It is important to note that the use of opioids can be associated with serious risks, including addiction, abuse, and overdose [1]. Therefore, it is essential to use opioids only as directed by a healthcare provider and to follow all safety precautions carefully.

In summary, based on the available information, there is no evidence to suggest that Lipitor enhances the effectiveness of opioids.

Sources:
[1] "Opioid Overdose Crisis." National Institute on Drug Abuse, 2 Feb. 2022, <https://www.drugabuse.gov/drug-topics/opioids/opioid-overdose-crisis>.
[2] "Lipitor." MedlinePlus, U.S. National Library of Medicine, 11 Feb. 2022, <https://medlineplus.gov/druginfo/meds/a601245.html>.