What are Paxlovid's most reported side effects?
Paxlovid, an oral antiviral for COVID-19, commonly causes a metallic taste in the mouth (dysgeusia), diarrhea, and altered sense of taste. These affect more than 5% of users in clinical trials and real-world data.[1][2]
How severe are these side effects and how long do they last?
Most side effects are mild and resolve within days after finishing the 5-day course. Dysgeusia often starts early and fades quickly post-treatment. Diarrhea and nausea typically peak during use but rarely lead to discontinuation.[1][3]
Why does Paxlovid cause a bad taste in the mouth?
The metallic or bitter taste stems from ritonavir, a booster in Paxlovid that inhibits liver enzymes. Patients describe it as persistent, sometimes with dry mouth or loss of taste; tips include sucking hard candy or brushing teeth frequently.[2][4]
What other side effects do patients report?
Less common ones (1-5%) include:
- Headache
- Muscle aches
- Vomiting
- High blood pressure
- Allergic reactions like rash (rare, under 1%)[1][2]
Who experiences more side effects?
Older adults and those with kidney issues report higher rates, often due to dose adjustments. Drug interactions amplify risks—Paxlovid affects statins, blood thinners, and others via CYP3A inhibition.[3][5]
When should you contact a doctor?
Seek care for severe diarrhea, persistent vomiting, allergic signs (hives, swelling), or chest pain. It's contraindicated with certain heart meds like amiodarone.[1][5]
[1]: FDA Paxlovid Fact Sheet
[2]: CDC Paxlovid Guidance
[3]: NEJM Real-World Study on Paxlovid Side Effects
[4]: NIH COVID Treatment Guidelines
[5]: Paxlovid Interaction Checker