See the DrugPatentWatch profile for Entacapone
What is entacapone, and what is it used for?
Entacapone is a medicine used with carbidopa/levodopa to treat symptoms of Parkinson’s disease, especially to help reduce “wearing off.” It works by blocking an enzyme (catechol-O-methyltransferase, or COMT) that breaks down levodopa, helping levodopa last longer so symptoms stay under better control [1].
How does entacapone work with levodopa/carbidopa?
Levodopa is the key ingredient in many Parkinson’s regimens, and carbidopa helps it work better in the body. Entacapone adds on by slowing the breakdown of levodopa, which can improve the duration of each dose and lessen fluctuations between dose times [1].
How is entacapone typically taken?
Entacapone is taken by mouth with doses of carbidopa/levodopa. Doctors often adjust timing so it’s taken with each levodopa dose that you take during the day (the exact schedule depends on the person’s levodopa regimen) [1].
What side effects should patients watch for?
Common side effects can include problems related to increased dopamine activity, such as diarrhea and other gastrointestinal effects, as well as dizziness or lightheadedness. Some people also notice urine discoloration (often dark/orange-brown), which is a known effect of COMT inhibitors like entacapone [1]. If a patient has severe diarrhea, signs of dehydration, fainting, or new confusion, they should contact their clinician promptly.
Who should not take entacapone (or who needs extra caution)?
Patients should follow their clinician’s instructions closely and discuss medical history before starting entacapone. Extra caution is especially important for people with liver problems, since COMT inhibitors can affect liver-related processes. It’s also important to review other medications, because drug interactions can change risk and tolerability [1].
What drug interactions matter?
Because entacapone affects neurotransmitter metabolism and is added to levodopa regimens, interaction risk comes both from Parkinson’s medicines and other drugs. People should provide a full medication list (including over-the-counter products) to their prescriber and pharmacist to check for interaction risks [1].
Can entacapone be stopped, and what happens if doses are missed?
Entacapone is usually taken as part of a planned dosing schedule with levodopa. Missing doses can reduce symptom control and may increase “wearing off.” Stopping should be done only with clinician guidance, since changing COMT inhibitor use can alter how levodopa works for that person [1].
Is entacapone still widely available, and is it a brand or generic?
Entacapone is available as a medication used in Parkinson’s disease and is known by its generic name, entacapone (brand availability can vary by country) [1].
---
Sources
[1] https://www.medicines.org.uk (entacapone: patient and professional prescribing information)