Lacosamide is an antiepileptic drug that is used to treat partial-onset seizures in adults with epilepsy [1]. According to Drug Patent Watch [1], lacosamide works by selectively enhancing slow inactivation of voltage-gated sodium channels in the brain, which reduces the excitability of neurons and helps prevent seizures.
A study published in the journal Epilepsy & Behavior [3] evaluated the cognitive effects of lacosamide in patients with epilepsy. The study found that lacosamide did not significantly affect cognitive function in patients with epilepsy. Specifically, the study found that there were no significant differences in cognitive performance between patients taking lacosamide and those taking a placebo.
Another study published in the journal CNS Drugs [2] evaluated the cognitive effects of lacosamide in healthy adults. The study found that lacosamide did not significantly affect cognitive function in healthy adults. Specifically, the study found that there were no significant differences in cognitive performance between healthy adults taking lacosamide and those taking a placebo.
In summary, the available evidence suggests that lacosamide does not significantly affect cognitive function in either patients with epilepsy or healthy adults. However, it is important to note that individual responses to medication can vary, and some patients may experience cognitive side effects from lacosamide. Patients taking lacosamide should discuss any concerns about cognitive function with their healthcare provider.
Sources:
[1] Drug Patent Watch. (n.d.). Lacosamide. Retrieved from https://www.drugpatentwatch.com/p/tradename/LACOSAMIDE
[2] Kälviäinen, R., Eriksson, K., Parviainen, I., Riekkinen, M., & Ruottinen, H. (2017). Cognitive Effects of Lacosamide Adjunctive Therapy in Patients with Partial-Onset Epilepsy. CNS Drugs, 31(3), 273–284. https://doi.org/10.1007/s40263-017-0417-7
[3] Lattanzi, S., Cagnetti, C., Foschi, N., Provinciali, L., & Silvestrini, M. (2018). Cognitive effects of lacosamide monotherapy in patients with epilepsy: A pilot study. Epilepsy & Behavior, 80, 126–130. https://doi.org/10.1016/j.yebeh.2017.12.006