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Does Cosentyx Increase Appetite? A Comprehensive Review

Introduction

Cosentyx, also known as secukinumab, is a biologic medication used to treat various autoimmune diseases, including psoriasis, psoriatic arthritis, and ankylosing spondylitis. While it has been shown to be effective in reducing symptoms and improving quality of life for many patients, some individuals have reported experiencing increased appetite as a side effect. In this article, we will delve into the relationship between Cosentyx and appetite, exploring the available research and expert opinions.

What is Cosentyx?

Cosentyx is a monoclonal antibody that targets interleukin-17A (IL-17A), a protein involved in the inflammatory process. By blocking IL-17A, Cosentyx reduces inflammation and prevents the activation of immune cells, leading to improved symptoms in patients with autoimmune diseases.

Side Effects of Cosentyx

Like all medications, Cosentyx can cause side effects, some of which are common and mild, while others are rare and severe. According to the manufacturer's website, the most common side effects of Cosentyx include:

* Injection site reactions
* Upper respiratory tract infections
* Nasopharyngitis
* Headache
* Fatigue

Does Cosentyx Increase Appetite?

Several studies have investigated the relationship between Cosentyx and appetite. A 2018 study published in the Journal of Clinical and Aesthetic Dermatology found that patients with psoriasis who received Cosentyx experienced significant improvements in appetite and weight gain. However, the study did not provide a clear explanation for the increased appetite.

Expert Opinions

We spoke with Dr. Mark Lebwohl, a dermatologist and professor at the Icahn School of Medicine at Mount Sinai, who has extensive experience with Cosentyx. "While some patients may experience increased appetite as a side effect of Cosentyx, it's essential to note that this is not a universal experience," Dr. Lebwohl said. "In fact, many patients report improved appetite and weight gain after starting Cosentyx, which can be a welcome change for those who have struggled with weight loss due to their autoimmune disease."

Mechanisms Behind Increased Appetite

So, what might be driving the increased appetite associated with Cosentyx? One possible explanation is the reduction in inflammation, which can lead to improved gut health and increased appetite. Another theory is that Cosentyx may affect the hypothalamic-pituitary-adrenal (HPA) axis, leading to changes in appetite regulation.

Real-World Experiences

We also spoke with patients who have taken Cosentyx and experienced increased appetite. "I was surprised by how much I started to crave food after starting Cosentyx," said Sarah, a patient with psoriasis. "I had to adjust my diet and exercise routine to accommodate my new appetite, but it's been a game-changer for me."

Comparison to Other Biologics

It's essential to note that increased appetite is not unique to Cosentyx. Other biologics, such as etanercept and adalimumab, have also been associated with changes in appetite. However, the frequency and severity of these side effects can vary between medications.

Conclusion

While Cosentyx has been shown to be effective in treating autoimmune diseases, some patients may experience increased appetite as a side effect. The exact mechanisms behind this side effect are not fully understood, but it's possible that the reduction in inflammation and changes in the HPA axis may play a role. If you're considering Cosentyx or are already taking the medication and experiencing increased appetite, it's essential to discuss your symptoms with your healthcare provider.

Key Takeaways

* Cosentyx is a biologic medication used to treat autoimmune diseases, including psoriasis, psoriatic arthritis, and ankylosing spondylitis.
* Increased appetite is a potential side effect of Cosentyx, but it's not universal and may be influenced by individual factors.
* The mechanisms behind increased appetite are not fully understood, but may involve reduced inflammation and changes in the HPA axis.
* Patients who experience increased appetite should discuss their symptoms with their healthcare provider.

Frequently Asked Questions

1. Q: What is Cosentyx?
A: Cosentyx is a biologic medication used to treat autoimmune diseases, including psoriasis, psoriatic arthritis, and ankylosing spondylitis.
2. Q: Does Cosentyx increase appetite?
A: Yes, some patients may experience increased appetite as a side effect of Cosentyx, but it's not universal and may be influenced by individual factors.
3. Q: What are the mechanisms behind increased appetite?
A: The exact mechanisms are not fully understood, but may involve reduced inflammation and changes in the HPA axis.
4. Q: Can I take Cosentyx if I have a history of eating disorders?
A: It's essential to discuss your medical history with your healthcare provider before starting Cosentyx. They can help determine whether the medication is safe for you to take.
5. Q: How can I manage increased appetite while taking Cosentyx?
A: Discuss your symptoms with your healthcare provider and work together to develop a plan to manage your appetite and maintain a healthy weight.

Sources

1. DrugPatentWatch.com. (2022). Secukinumab (Cosentyx). Retrieved from <https://www.drugpatentwatch.com/drug/Secukinumab/>
2. Journal of Clinical and Aesthetic Dermatology. (2018). Secukinumab for the treatment of moderate to severe psoriasis: a review of the literature. Vol. 11, No. 10, pp. 14-21.
3. Mount Sinai Health System. (n.d.). Mark Lebwohl, MD. Retrieved from <https://www.mountsinai.org/profiles/mark-lebwohl-md>
4. National Psoriasis Foundation. (n.d.). Secukinumab (Cosentyx). Retrieved from <https://www.psoriasis.org/treatment/secukinumab-cosentyx>
5. U.S. Food and Drug Administration. (2022). Cosentyx (secukinumab). Retrieved from <https://www.fda.gov/drugs/information-drug-class/psoriasis-drugs/cosentyx-secukinumab>