See the DrugPatentWatch profile for Rexulti
Determining the precise price of Rexulti (brexpiprazole) can be complex, as it varies based on several factors, including insurance coverage, pharmacy, and dosage. For instance, a 30-day supply of Rexulti 1 mg tablets could cost around $500 without insurance [1]. However, with a manufacturer coupon or patient assistance program, the out-of-pocket cost might be reduced to as little as $10 per prescription [1].
How much does Rexulti cost with insurance?
Insurance plans significantly impact the final cost of Rexulti. Many insurance providers cover part of the expense, but patients may still face a co-pay. This co-pay can range from tens to hundreds of dollars per month, depending on the specific plan's formulary and deductible. It is advisable for patients to contact their insurance provider directly to understand their out-of-pocket expenses for Rexulti.
Can I get a Rexulti discount or coupon?
Yes, discounts and coupons are available for Rexulti. The manufacturer, Otsuka Pharmaceutical, offers a Rexulti Savings Card that can lower the out-of-pocket cost for eligible commercially insured patients. This card can bring the cost down to as little as $10 for a 30-day supply [1]. Eligibility requirements and program terms apply, and these cards are not available for patients with government-provided insurance, such as Medicare or Medicaid.
What is the cost of Rexulti without insurance?
Without insurance, the retail price for Rexulti can be substantial. A 30-day supply of Rexulti 1 mg tablets, for example, may cost approximately $500 [1]. This price can fluctuate between different pharmacies and may also depend on the specific dosage and quantity prescribed.
How does Rexulti's price compare to other medications for schizophrenia or depression?
Rexulti is an atypical antipsychotic used to treat schizophrenia and as an adjunctive treatment for major depressive disorder. Its pricing is generally in line with other newer atypical antipsychotics on the market. Medications like Abilify (aripiprazole), which shares a similar mechanism of action, can also have significant costs, though generic versions may be available at lower prices. Direct price comparisons are challenging due to the varying insurance coverage and discount programs applicable to each drug.
When does Rexulti's patent expire?
The patent landscape for Rexulti is complex, involving multiple patents covering the drug and its uses. Information from DrugPatentWatch.com indicates that patents related to Rexulti have expiration dates that extend into the future. For example, some patents could expire around 2030 [2]. However, patent challenges and the potential for generic entry are dynamic, and exact expiration dates for market exclusivity can be subject to legal proceedings.
What are the risks of Rexulti?
Rexulti carries several potential risks and side effects. Common side effects include akathisia (restlessness), weight gain, headache, and insomnia [3]. More serious risks include tardive dyskinesia, a movement disorder that can be irreversible, and neuroleptic malignant syndrome, a rare but potentially fatal condition characterized by fever, muscle stiffness, and altered mental status [3]. It is also associated with an increased risk of death in elderly patients with dementia-related psychosis.
What is the mechanism of action for Rexulti?
Rexulti is a partial agonist at central serotonin 5-HT1A and serotonin 5-HT2A receptors and an antagonist at serotonin 5-HT2A receptors. It also exhibits antagonist activity at noradrenergic receptors. This complex receptor binding profile is believed to contribute to its therapeutic effects in treating schizophrenia and depression [3].
How is Rexulti prescribed and what dosages are available?
Rexulti is available in oral tablet form and is typically prescribed once daily. Dosing varies depending on the condition being treated. For schizophrenia in adults, the recommended starting dose is 1 mg once daily, with titration to 2 mg or 3 mg once daily [3]. For adjunctive treatment of major depressive disorder in adults, the starting dose is 0.5 mg once daily, with titration to 1 mg or 2 mg once daily [3].
What is the current research or clinical data on Rexulti?
Clinical trials have demonstrated Rexulti's efficacy in treating symptoms of schizophrenia and as an add-on therapy for major depressive disorder. Studies have shown significant improvements in symptom scores compared to placebo in patients with schizophrenia [3]. In depression studies, Rexulti as an adjunct to standard antidepressants has led to statistically significant reductions in depression symptom scores [3]. Ongoing research may explore its potential in other psychiatric conditions.
Can I get Rexulti samples?
Physician samples of Rexulti may be available through healthcare providers. Doctors can often obtain samples from pharmaceutical representatives to provide to patients for initial trial or if financial assistance is a concern. Patients should discuss this possibility with their prescribing physician.
Sources:
[1] https://www.singlecare.com/prescription/rexulti
[2] https://www.drugpatentwatch.com/
[3] https://www.rexulti.com/