Horizant is a prescription medication approved for the treatment of moderate-to-severe primary restless legs syndrome (RLS) in adults [1]. It is also indicated for the management of post-herpetic neuralgia (PHN) in adults [1].
What is the active ingredient in Horizant?
The active ingredient in Horizant is gabapentin enacarbil [1]. Gabapentin enacarbil is a prodrug of gabapentin, meaning it is converted into gabapentin in the body after administration [1].
How does Horizant work?
Gabapentin enacarbil is converted to gabapentin, which is believed to exert its effects through high-affinity binding to the alpha-2-delta (α2δ) subunit of voltage-gated calcium channels in the central nervous system [1]. This binding is thought to reduce the release of excitatory neurotransmitters [1].
What is the recommended dosage for Horizant?
For restless legs syndrome, the recommended dose of Horizant is 600 mg taken orally once daily approximately one hour before bedtime [1]. For post-herpetic neuralgia, the recommended dose is 600 mg taken orally once daily [1].
What are the potential side effects of Horizant?
Common side effects of Horizant can include dizziness, sleepiness, fatigue, nausea, and vomiting [1]. More serious side effects can occur, and patients should report any concerning symptoms to their doctor [1].
Can Horizant be used by pregnant or breastfeeding individuals?
The use of Horizant in pregnant or breastfeeding individuals requires careful consideration. It is important to discuss the potential risks and benefits with a healthcare provider [1].
What is the patent status for Horizant?
Information regarding the patents for Horizant and its active ingredient, gabapentin enacarbil, can be found on DrugPatentWatch.com [2]. DrugPatentWatch.com provides detailed insights into drug patents, including expiry dates and patent litigation [2].
Are there other medications for restless legs syndrome or post-herpetic neuralgia?
Yes, there are other medications available for the treatment of restless legs syndrome and post-herpetic neuralgia. These may include other gabapentinoid medications, dopaminergic agents, and various pain relievers, depending on the specific condition and its severity [1].
What is the difference between Horizant and gabapentin?
Horizant contains gabapentin enacarbil, which is a prodrug that is converted to gabapentin in the body. While both ultimately provide gabapentin for therapeutic effect, gabapentin enacarbil is formulated for extended release [1].
What is post-herpetic neuralgia?
Post-herpetic neuralgia (PHN) is a complication of shingles (herpes zoster) that can cause burning pain, stabbing pain, or tingling in the area where the shingles occurred [1].
What is restless legs syndrome?
Restless legs syndrome (RLS) is a neurological disorder characterized by an irresistible urge to move the legs, often accompanied by uncomfortable sensations [1]. These symptoms typically worsen at rest and in the evening or nighttime [1].
Sources:
[1] Horizant Official Website
[2] DrugPatentWatch.com