Based on the information available, there is a potential interaction between Lipitor (atorvastatin), a statin medication used to treat high cholesterol, and certain selective serotonin reuptake inhibitors (SSRIs), a class of antidepressants. However, it's important to note that the risk of muscle damage, specifically rhabdomyolysis, is relatively low [1].

Lipitor can increase the levels of SSRIs in the body, and some SSRIs may increase the risk of muscle damage when taken with Lipitor. The SSRIs primarily associated with this interaction include fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), and possibly sertraline (Zoloft) [1][2].

Symptoms of muscle damage can include muscle pain, tenderness, or weakness, especially if accompanied by dark or reddish-brown urine [1]. If you experience these symptoms while taking Lipitor and an SSRI, you should contact your healthcare provider immediately.

However, it's important to remember that not all SSRIs have been definitively linked to an increased risk of muscle damage when taken with Lipitor. Furthermore, the benefits of these medications often outweigh the potential risks when used as directed by a healthcare professional [1][2].

In conclusion, while there is a potential interaction between Lipitor and certain SSRIs that could lead to muscle damage, the risk is relatively low. Patients should consult with their healthcare provider if they have concerns about potential drug interactions.

Sources:
[1] Drugs.com. (2021). Atorvastatin and Muscle Pain. Retrieved from https://www.drugs.com/atorvastatin.html
[2] DrugPatentWatch.com. (2021). Atorvastatin. Retrieved from https://www.drugpatentwatch.com/drugs/atorvastatin