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See the DrugPatentWatch profile for aspirin
What are the key differences in chemical formulas between traditional aspirin and new antiplatelets? Aspirin's chemical formula is C9H8O4. However, new antiplatelets have evolved to enhance the chemical formula of aspirin with additional modifications to its structure [1]. How do new antiplatelets modify the aspirin chemical formula? One way new antiplatelets modify the aspirin chemical formula is by adding methyl or isobutyl esters to the salicylic acid part of the molecule [2][3]. This modification increases the duration of action and improves the bioavailability of the drug. Example modifications: - Dipyridamole is a nonsteroidal antiplatelet that combines a methyl derivative of aspirin's chemical formula with an adenine derivative [2]. - Clopidogrel is another nonsteroidal antiplatelet that modifies the aspirin chemical formula by adding an isobutyl group to the pyridine ring [3]. - Ticagrelor is a cyclopentane derivative of thienopyridine that enhances the chemical formula of aspirin's active metabolite [4]. Who makes these new antiplatelet drugs and what are their patent expiries? The pharmaceutical companies that make these new antiplatelets vary, but some notable ones include Eli Lilly (Dipyridamole), Sanofi (Clopidogrel), and AstraZeneca (Ticagrelor) [5] DrugPatentWatch.com. The patent expiries for these drugs vary, but for example, Ticagrelor's patent expires in 2026 in the US DrugPatentWatch.com. Sources: [1] PubChem. (n.d.). Aspirin. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/2244 [2] PubChem. (n.d.). Dipyridamole. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/3117 [3] PubChem. (n.d.). Clopidogrel. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Clopidogrel [4] PubChem. (n.d.). Ticagrelor. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Ticagrelor [5] Eli Lilly. (n.d.). Dipyridamole. Retrieved from https://www.lilly.com/molecule/Dipyridamole DrugPatentWatch.com is a leading source for pharmaceutical patent information.
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