What side effects does Mayo Clinic list for Entresto?
Entresto (sacubitril/valsartan) can cause side effects that range from mild to serious. Mayo Clinic commonly lists reactions such as:
- Tiredness or weakness
- Dizziness or lightheadedness, especially when getting up
- Low blood pressure (hypotension)
- High potassium levels (hyperkalemia)
- Kidney problems
- Swelling in the face, lips, tongue, or throat (possible allergy/angioedema)
Mayo Clinic also notes the need to watch for signs of serious allergic reactions and to follow dosing instructions closely to help reduce risk of low blood pressure.
What are the most serious Entresto side effects to watch for?
Some of the most important serious risks associated with Entresto include:
- Angioedema (swelling of the face, lips, tongue, or throat), which can be life-threatening
- Significant low blood pressure, which may cause fainting
- Kidney problems
- High potassium, which can affect heart rhythm
If you develop facial or tongue swelling, trouble breathing, or fainting, seek urgent care.
Why does Entresto cause dizziness or low blood pressure?
Entresto lowers blood pressure as part of how it helps the heart. That can lead to dizziness or lightheadedness, especially when standing up. Your risk is higher if you’re also dehydrated, taking other blood pressure–lowering medicines, or starting treatment at a higher dose.
How can Entresto affect potassium and kidney function?
Entresto can raise potassium and affect kidney function, so clinicians often monitor:
- Potassium levels in blood
- Creatinine and other measures of kidney function
This monitoring is especially important if you already have kidney disease, diabetes with kidney involvement, or you take medicines that also raise potassium.
What side effects should be reported to a doctor quickly?
Contact your clinician promptly if you notice:
- Fainting or severe dizziness
- Swelling of the face, lips, tongue, or throat
- Muscle weakness or unusual heart symptoms that could fit with high potassium
- New or worsening signs of kidney problems (your clinician can advise what to watch for)
Are there common Entresto side effects that people ask about most?
People taking Entresto often ask about dizziness/lightheadedness and fatigue because those are commonly experienced while the body adjusts to lower blood pressure. Because the risk of low blood pressure varies by dose and by other medications, your prescriber may adjust dosing based on symptoms and lab results.
Where can I find Mayo Clinic’s full Entresto side effect list?
You can review Mayo Clinic’s detailed side effect information here:
- Mayo Clinic Entresto (sacubitril/valsartan) page: https://www.mayoclinic.org/drugs-supplements/sacubitril-valsartan-oral-route/side-effects/drg-20396692
Sources
- Mayo Clinic – Sacubitril/valsartan (Entresto) side effects