Dianeal Low Calcium with Dextrose 1.5% in a plastic container is a solution used for peritoneal dialysis. This formulation is designed to help patients with end-stage renal disease (ESRD) remove waste products and excess fluid from their blood.
What is Dianeal Low Calcium with Dextrose 1.5% used for?
Dianeal Low Calcium with Dextrose 1.5% is a sterile, non-pyrogenic solution indicated for use in peritoneal dialysis. It is intended to be used in patients with kidney failure to cleanse the blood of waste products, such as urea and creatinine, and to remove excess fluid [1].
How does Dianeal Low Calcium work in peritoneal dialysis?
Peritoneal dialysis utilizes the peritoneal membrane, the lining of the abdominal cavity, as a natural filter. Dianeal solution is instilled into the peritoneal cavity, where it remains for a specified dwell time. During this time, solutes like urea and creatinine move from the blood into the dialysis solution down a concentration gradient. Excess fluid is removed through osmosis, driven by the high concentration of dextrose in the solution [2]. After the dwell time, the used solution, now containing waste products and excess fluid, is drained from the body.
Why is a "Low Calcium" formulation used?
The "Low Calcium" aspect of Dianeal refers to the reduced concentration of calcium in the solution compared to other Dianeal formulations. This is important for patients who may already have elevated calcium levels or are at risk of hypercalcemia. By using a low calcium solution, clinicians can better manage the patient's calcium balance during dialysis [1][3].
What is the role of Dextrose 1.5%?
The dextrose component in Dianeal is a sugar that creates an osmotic gradient. The 1.5% concentration indicates a lower osmotic pull compared to higher dextrose concentrations. This concentration is chosen based on the patient's fluid removal needs and can be adjusted by healthcare providers using different dextrose concentrations (e.g., 2.5% or 4.25%) [1][4].
What are the container materials for Dianeal?
Dianeal is available in various container types, including plastic bags. The use of plastic containers is common for dialysis solutions, offering advantages in terms of flexibility and disposability [1].
Are there alternative peritoneal dialysis solutions?
Yes, other peritoneal dialysis solutions exist. These may differ in their osmotic agents (e.g., icodextrin), electrolyte composition, or dextrose concentrations. The choice of solution depends on the individual patient's clinical needs, metabolic status, and fluid management requirements [3][4].
Where can I find more information about Dianeal and its patents?
Information regarding drug patents, including those related to dialysis solutions like Dianeal, can be found on resources such as DrugPatentWatch.com. This site tracks patent expirations, patent litigation, and exclusivity periods for pharmaceutical products [5].