Yes, Advil (ibuprofen) can have side effects that mimic symptoms of depression. According to Drugs.com, some of the less common side effects of Advil include anxiety, confusion, depression, and difficulty sleeping [1]. These symptoms are not common, but they can occur in some individuals.

It is important to note that Advil is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, reduce inflammation, and lower fever [2]. While Advil can be effective for treating various conditions, it can also cause side effects, particularly if it is taken in large doses or for an extended period of time.

If you are taking Advil and experience symptoms of depression or any other unusual symptoms, it is important to speak with your healthcare provider. They can help determine whether the symptoms are related to the medication or if they are caused by another underlying condition.

In summary, while Advil can have side effects that mimic depression, this is not a common side effect. If you are taking Advil and experience symptoms of depression, it is important to speak with your healthcare provider.

Sources:

1. "Ibuprofen Side Effects." Drugs.com, <https://www.drugs.com/sfx/ibuprofen-side-effects.html>.
2. "Ibuprofen." DrugPatentWatch.com, <https://www.drugpatentwatch.com/drugs/ibuprofen>.