Is it safe to take advil while on antidepressants and what should i consider?

Risks of Combining Advil and Antidepressants

Taking Advil (ibuprofen) while on antidepressants can be safe for some people, but it's crucial to consider potential interactions and risks. Advil is a nonsteroidal anti-inflammatory drug (NSAID) that can increase blood pressure and affect kidney function, which may be problematic when combined with certain antidepressants.

Why is it a concern?

[1] The FDA warns that combining NSAIDs like Advil with certain antidepressants, such as MAOIs (monoamine oxidase inhibitors), can lead to serotonin syndrome, a potentially life-threatening condition characterized by symptoms like confusion, agitation, rapid heart rate, and changes in blood pressure.

Types of Antidepressants and Potential Interactions

* Selectivity of serotonin reuptake inhibitors (SSRIs): Although SSRIs like Prozac and Zoloft are generally considered safe with NSAIDs, it's essential to monitor for increased bleeding risks. Studies suggest that combining SSRIs with NSAIDs like Advil may increase the risk of gastrointestinal bleeding, especially in older adults. [2]
* Tricyclic antidepressants (TCAs): Combining TCAs with NSAIDs like Advil may increase the risk of serotonin syndrome, kidney damage, and changes in blood pressure.
* Other antidepressants: Some antidepressants, such as bupropion (Wellbutrin), interact with NSAIDs and may cause seizures, serotonin syndrome, or other adverse effects. [3]

What to Consider Before Taking Advil on Antidepressants

* Discuss with your doctor: Before taking Advil, inform your doctor about your antidepressant medication and any other health conditions you have.
* Assess your risks: Your doctor can help you weigh the potential benefits and risks of combining Advil with your antidepressants.
* Monitor your body: Pay attention to any changes in your body, such as increased bleeding, dizziness, or changes in blood pressure.
* Alternative pain relief options: Consider other pain relief options, such as acetaminophen (Tylenol), which may be safer for people taking antidepressants.

References

[1] FDA: "Serotonin Syndrome and MAOIs"
[2] Journal of Clinical Psychopharmacology: "Gastrointestinal bleeding and antiplatelet agents: A systematic review and meta-analysis"
[3] National Institute of Mental Health: "Bupropion and seizures: Information for patients and families"

Sources

* DrugPatentWatch.com
* FDA - Food and Drug Administration
* Journal of Clinical Psychopharmacology
* National Institute of Mental Health