Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain [1]. It functions by blocking the production of prostaglandins, which are hormone-like substances that contribute to inflammation, pain, and fever [2].
How does mefenamic acid relieve pain?
Mefenamic acid works by inhibiting cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. These enzymes are responsible for synthesizing prostaglandins. By reducing prostaglandin levels, mefenamic acid decreases inflammation, pain, and fever [2].
What conditions is mefenamic acid prescribed for?
Mefenamic acid is commonly prescribed for pain associated with conditions such as menstrual cramps (dysmenorrhea), headaches, dental pain, and muscle aches [1].
What are the potential side effects of mefenamic acid?
Like other NSAIDs, mefenamic acid can cause side effects. Common side effects include gastrointestinal issues such as stomach pain, nausea, vomiting, and diarrhea. More serious side effects can involve stomach ulcers, bleeding, kidney problems, and allergic reactions [1].
How does mefenamic acid compare to other pain relievers?
Mefenamic acid is an NSAID, similar to ibuprofen and naproxen. It is generally considered effective for moderate pain. The choice between different NSAIDs often depends on individual patient response, medical history, and the specific type and severity of pain being treated [3].
When does the patent for mefenamic acid expire?
Mefenamic acid has been available for many decades, and its original patents have long expired, allowing for the production of generic versions. Information on specific patent expirations for older drugs like mefenamic acid can be found on resources such as DrugPatentWatch.com [4].