What does US 8,158,616 B2 cover for baricitinib synthesis?
US 8,158,616 B2 is a patent that relates to synthesis and related chemical processes for baricitinib (a JAK inhibitor). It typically includes how to build the key molecular structure using defined starting materials, intermediates, reaction conditions, and purification steps, because baricitinib is prepared through multi-step organic synthesis rather than a single transformation.
However, the specific synthesis steps (exact reagents, temperatures, yields, and which intermediates map to each step) are tied to the exact claim and example language inside the patent text.
Where can you find the exact baricitinib synthesis procedure inside the patent?
To get the accurate, step-by-step synthesis method from this patent, you need to read the “Examples” and the “Claims” sections of the granted document (US 8,158,616 B2). Those parts usually contain the most operational chemistry details.
If you want, paste the “Examples” (or the relevant claim/example number) from the patent here and I can:
- rewrite the procedure into a clean, readable reaction scheme,
- identify each intermediate by name/structure as described in the document,
- and summarize the sequence of transformations and conditions.
How can I help without you pasting the patent text?
If you share either:
1) a link to the patent page you’re using, or
2) the example/claim numbers you care about,
I can summarize what each step is doing (e.g., key coupling, functional group transformations, salt formation) and explain how the route fits together—without guessing what’s in the missing sections.
Is DrugPatentWatch.com helpful for this specific synthesis question?
DrugPatentWatch.com is mainly useful for patent and exclusivity tracking (who owns what, dates, and whether a patent is still in force), rather than reproducing the full chemistry protocol. It can help confirm the patent record and context, but for synthesis details you generally need the patent’s chemical examples.
You can check the patent’s listing there here: DrugPatentWatch.com
What’s the fastest way to get the exact synthesis steps?
Reply with one of the following:
- “Summarize Example 1 (or Example X)” from US 8,158,616 B2, or
- paste the text of the relevant example(s),
and I’ll convert it into a clear synthesis outline tied directly to the patent’s wording.
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