Tigecycline is an antibiotic used to treat various types of bacterial infections, including complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia [1][2]. However, like many medications, tigecycline can cause adverse effects.

According to the Mayo Clinic, the most common side effects of tigecycline include nausea and vomiting, which occur in more than 25% of people taking the medication [2]. Diarrhea and headache are also common, affecting between 1-10% of people taking tigecycline [2].

In addition to these common side effects, tigecycline has several other potential adverse effects. The drug can cause serious liver problems, including liver failure and death [2]. It can also increase the risk of death in patients with certain types of infections, such as ventilator-associated pneumonia and complicated intra-abdominal infections [2].

Tigecycline may also affect the normal bacteria that live in the digestive system, leading to an overgrowth of harmful bacteria [3]. This can cause diarrhea, abdominal pain, and fever [3].

Other potential adverse effects of tigecycline include allergic reactions, changes in blood pressure, and changes in heart rate [2].

In summary, tigecycline can cause a range of adverse effects, including nausea, vomiting, diarrhea, headache, and liver problems. It may also affect the normal bacteria in the digestive system and increase the risk of death in certain patients.

Sources:
[1] DrugPatentWatch. (n.d.). Tigecycline. Retrieved from <https://www.drugpatentwatch.com/p/tradename/TIGECYCLINE>
[2] Mayo Clinic. (2021). Tigecycline (Intravenous route) side effects. Retrieved from <https://www.mayoclinic.org/drugs-supplements/tigecycline-intravenous-route/side-effects/drg-20072556>
[3] Friedman, J. (2006). Tigecycline: A review of its use in the treatment of intra-abdominal infections. US Pharmacist, 31(12), 34-42. Retrieved from <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1426172/>