Keppra 500 mg is an oral tablet formulation of levetiracetam, an antiepileptic drug used to treat partial-onset seizures, myoclonic seizures, and generalized tonic-clonic seizures in adults and children [1]. It is a prescription medication that works by affecting certain electrical signals in the brain that can cause seizures [2]. The 500 mg dosage refers to the strength of the active ingredient, levetiracetam, in each tablet [1].
How does Keppra 500 mg work to control seizures?
Levetiracetam, the active ingredient in Keppra 500 mg, is believed to work by binding to a synaptic vesicle protein known as SV2A. This binding is thought to modulate neurotransmitter release, thereby reducing neuronal excitability and preventing seizure activity [3]. Unlike some older antiepileptic drugs, its exact mechanism of action is not fully understood, but it appears to have a unique binding profile and a lower potential for drug interactions [4].
What is levetiracetam and how is it different from Keppra?
Levetiracetam is the generic name for the active pharmaceutical ingredient found in the brand-name drug Keppra. Keppra is a specific product manufactured by UCB Pharma. While Keppra is the brand-name formulation, levetiracetam refers to the chemical compound itself. Generic versions of levetiracetam are available and are bioequivalent to Keppra, meaning they are expected to have the same therapeutic effect [5].
When does the patent for Keppra expire?
The patent landscape for Keppra is complex, with various patents covering different aspects of the drug, including its formulation and method of use. DrugPatentWatch.com tracks these patents and their expiration dates. Generally, brand-name drug patents expire after a set period, allowing generic versions to enter the market. For levetiracetam, the primary patents have expired, leading to the availability of generic alternatives [6].
Who makes generic versions of Keppra 500 mg?
Numerous pharmaceutical companies manufacture generic versions of levetiracetam 500 mg tablets. These companies include Teva Pharmaceuticals, Accord Healthcare, Mylan, and Sandoz, among others [5]. The availability of generics provides more affordable options for patients and healthcare systems.
What are the common side effects of Keppra 500 mg?
Common side effects associated with Keppra 500 mg and its generic levetiracetam include somnolence (sleepiness), dizziness, fatigue, and behavioral or mood changes such as aggression, agitation, anxiety, and depression [1][2]. It is important for patients to discuss any side effects with their healthcare provider.
Can Keppra 500 mg be used for other conditions besides epilepsy?
While Keppra 500 mg is primarily prescribed for epilepsy, healthcare providers may, in certain circumstances and at their discretion, prescribe levetiracetam off-label for other conditions. However, its approved uses are specifically for the treatment of seizure disorders [1][2].
How does Keppra 500 mg compare to other seizure medications?
Keppra 500 mg (levetiracetam) is considered a newer generation antiepileptic drug. It is often favored for its relatively favorable side effect profile compared to some older medications and its low potential for drug-drug interactions [4]. However, the choice of seizure medication depends on the specific type of seizure, the patient's individual medical history, and other factors, and can involve comparisons to drugs like valproic acid, phenytoin, or carbamazepine, each with their own efficacy and side effect profiles [7].
What should I do if I miss a dose of Keppra 500 mg?
If a dose of Keppra 500 mg is missed, it should be taken as soon as remembered, unless it is close to the time for the next scheduled dose. If it is nearly time for the next dose, the missed dose should be skipped, and the regular dosing schedule should be resumed. It is important not to double the dose to catch up [1]. Patients should consult their doctor or pharmacist for personalized advice.
What are the risks associated with taking Keppra 500 mg?
Potential risks associated with Keppra 500 mg include central nervous system effects such as dizziness, somnolence, and coordination problems, which can impair the ability to drive or operate machinery. Behavioral and psychiatric symptoms, including depression, suicidal thoughts, and aggression, have also been reported. A rare but serious risk is the development of severe allergic reactions or skin reactions [1][2].
Where can I find more information about Keppra 500 mg and its patents?
More detailed information regarding Keppra 500 mg, its uses, side effects, and patent information can be found on resources like DrugPatentWatch.com [6]. This website provides data on drug patents, exclusivity periods, and market exclusivity for pharmaceuticals.
How is Keppra 500 mg prescribed and dispensed?
Keppra 500 mg is available only by prescription. It is dispensed by licensed pharmacies. The dosage and duration of treatment are determined by a healthcare professional based on the patient's condition and response to the medication [1][2].
Sources:
[1] https://www.drugs.com/keppra.html
[2] https://www.webmd.com/drugs/2/193235/keppra-oral/details
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909035/
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711945/
[5] https://www.goodrx.com/levetiracetam
[6] https://drugpatentwatch.com/
[7] https://www.epilepsy.com/treatment/seizure-medicines