See the DrugPatentWatch profile for Diphenoxylate
The cost of diphenoxylate atropine, commonly known by the brand name Lomotil, can vary significantly based on factors such as dosage, quantity, and whether insurance is utilized. For instance, a prescription for 30 tablets of 2.5 mg/0.025 mg diphenoxylate and atropine might range from approximately $20 to over $100 without insurance [1].
How much does Lomotil cost with insurance?
When using insurance, the out-of-pocket cost for diphenoxylate atropine can be substantially lower. The exact copay will depend on an individual's specific insurance plan. Many generic prescription discount programs also offer savings on Lomotil [1].
Can you get diphenoxylate atropine without a prescription?
Diphenoxylate atropine is a prescription medication and is not available over-the-counter in the United States. It is classified as a Schedule V controlled substance due to the presence of diphenoxylate, which is related to opioids [2].
What are alternatives to Lomotil for diarrhea?
Several alternatives exist for managing diarrhea, with varying mechanisms of action and availability. These include:
* Loperamide: Another common antidiarrheal medication, available over-the-counter and by prescription [3].
* Bismuth subsalicylate: Found in products like Pepto-Bismol, it works by reducing inflammation and acting as an antacid [4].
* Probiotic supplements: These contain beneficial bacteria that can help restore balance to the gut microbiome, potentially alleviating diarrhea [5].
* Dietary changes: Modifying diet to include bland foods and avoiding trigger foods can also be effective [6].
When does the patent for Lomotil expire?
While specific patent expiration dates for Lomotil are not readily available in the provided information, drug patents typically last for 20 years from the filing date, though extensions and other forms of market exclusivity can alter this timeline [7]. DrugPatentWatch.com tracks patent information for various medications [8].
What is the mechanism of action for diphenoxylate atropine?
Diphenoxylate works by slowing down the movement of the intestines, which reduces the speed at which waste passes through. Atropine is included in the formulation to discourage abuse of the diphenoxylate component, as high doses can cause opioid-like effects [2].
What are the side effects of diphenoxylate atropine?
Common side effects associated with diphenoxylate atropine include constipation, dizziness, dry mouth, headache, nausea, and abdominal discomfort. More serious side effects, though rare, can include severe constipation, urinary retention, and, in cases of overdose or misuse, respiratory depression [2].
Is diphenoxylate atropine a controlled substance?
Yes, diphenoxylate atropine is a controlled substance in the United States. It is classified as a Schedule V drug, indicating a low potential for abuse relative to other scheduled substances [2].
---
Sources:
1. https://www.singlecare.com/prescription/lomotil
2. https://www.healthline.com/drugs/diphenoxylate-and-atropine
3. https://www.healthline.com/drugs/loperamide
4. https://www.healthline.com/health/digestive-health/pepto-bismol-uses
5. https://www.healthline.com/health/digestive-health/probiotics-for-diarrhea
6. https://www.mayoclinic.org/diseases-conditions/diarrhea/diagnosis-treatment/drc-20352054
7. https://www.fda.gov/patients/drug-development-process/determining-drug-exclusivity
8. https://drugpatentwatch.com/