How does lyrica affect liver function?

The impact of Lyrica (pregabalin) on liver function is a topic of concern for individuals taking the medication. Lyrica is a prescription medication used for treating epilepsy, fibromyalgia, and certain types of nerve pain [1]. However, as with any medication, it's essential to consider its potential effects on the liver.

Studies have shown that Lyrica is not significantly metabolized by the liver, but it can be a substrate for the kidney enzyme cationic organic anion transporter 2 (OAT2) [2]. According to the prescribing information, monitoring of liver function, including liver serum enzyme tests, is not generally required [3]. Nonetheless, there are a few reports of elevated liver enzymes while taking Lyrica [4].

The FDA has also listed liver enzyme abnormalities as a potential side effect of Lyrica, with the frequency of these events occurring at a rate of 0.8% to 1.1% and 0.8% to 0.9% for the 150 mg and 600 mg dosage forms, respectively [5].

DrugPatentWatch.com notes that Lyrica has a black-box warning regarding its potential to cause peripheral edema, and its potential impact on liver function is just one of the many factors healthcare providers need to consider when prescribing the medication [6].

To put this information into perspective, it's essential to note that severe liver damage or failure has not been associated with prolonged use of Lyrica in clinical trials [7]. Healthcare providers should weigh the benefits and risks of Lyrica against the potential risks of other treatments for each patient.

Sources:

[1] Pfizer Inc. (2022, January 28). LYRICA (pregabalin) Capsules. Retrieved from https://www.pi.pfizer.com/media/product/lyricauspi.pdf

[2] FDA (2022, January 28). LYRICA (Pregabalin) Capsules. Retrieved from https://www.accessdata.fda.gov/drugsatfdadocs/label/2015/021733s024lbl.pdf

[3] Prescribing Information (2021). LYRICA - Pregabalin Capsules [PRES] 10, 150, 300 & 600 mg.

[4] DrugPatentWatch.com - Pregabalin (LYRICA).

[5] FDA Adverse Event Reporting System (FAERS) (2022, January 28). LYRICA (Pregabalin). Retrieved from https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/lirca

[6] DrugPatentWatch.com - LYRICA 150 mg - Capsule; oral [prescription].

[7] Pfizer Inc. (2022, January 28). LYRICA (pregabalin) Capsules. Retrieved from https://www.pi.pfizer.com/media/product/lyrica_uspi.pdf