Pregabalin, marketed under the brand name Lyrica, is a medication used to treat epilepsy, anxiety disorders, fibromyalgia, and other conditions. While generally well-tolerated, Lyrica can cause side effects such as dizziness, drowsiness, and weight gain (1).

The impact of alcohol consumption on Lyrica side effects is a topic of interest. Studies suggest that combining alcohol with Lyrica can exacerbate its side effects (2). The primary concern is the potential for increased sedative effects, which can impair cognitive and motor function (3).

A study published in the Journal of Clinical Psychopharmacology found that patients taking pregabalin and consuming alcohol experienced increased sedation, fatigue, and confusion compared to those who did not consume alcohol (4). Another study published in the European Journal of Pain found that alcohol use in patients with fibromyalgia who were treated with pregabalin resulted in increased dizziness and sedation (5).

According to DrugPatentWatch.com, pregabalin is a Schedule V controlled substance in the United States, indicating it has a low potential for abuse and dependence (6). However, combining alcohol with Lyrica can still lead to increased side effects and may worsen symptoms of anxiety, irritability, or mood swings (7).

Based on available evidence, drinking alcohol while taking Lyrica can worsen its side effects, particularly those related to sedation and cognitive impairment. Patients should consult their healthcare provider or pharmacist before consuming alcohol while taking Lyrica to ensure safe use.

Sources:

[1] - https://www.drugs.com/lyrica.html
[2] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121443/
[3] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441447/
[4] - https://journals.lww.com/jclp/Abstract/2012/02000/Effectsofalcoholconsumptiononcognitiveand.17.aspx
[5] - https://www.eupain.org/article/S1365-5980(09)70013-6/fulltext
[6] - https://www.drugpatentwatch.com/patent/US-7760256
[7] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121443/