A generic version of Rexulti is not yet available in the United States [1]. Rexulti, also known by its generic name brexpiprazole, is an antipsychotic medication used to treat schizophrenia and as an add-on treatment for major depressive disorder [2].
When Might a Generic Rexulti Become Available?
The patent expiry for Rexulti will determine when generic versions can enter the market [1]. Patent protection generally lasts for 20 years from the filing date of the patent application [3].
Who Manufactures Rexulti?
Rexulti is manufactured by Otsuka Pharmaceutical Co., Ltd. [4].
What is Brexpiprazole Used For?
Brexpiprazole is approved for the treatment of schizophrenia in adults and adolescents aged 13 and older [2]. It is also used as an adjunctive therapy for major depressive disorder in adults [2]. The medication works by affecting the activity of dopamine and serotonin in the brain [5].
Are There Legal Challenges to Rexulti's Patents?
Patent litigation is common for branded drugs, and challenges can impact the timeline for generic entry [1]. Information on specific patent challenges or litigation concerning Rexulti's patents can be found through resources like DrugPatentWatch.com [1].
What Are the Potential Risks and Side Effects of Brexpiprazole?
Like all medications, brexpiprazole carries potential risks and side effects. These can include serious side effects such as neuroleptic malignant syndrome, tardive dyskinesia, metabolic changes (like increased blood sugar and cholesterol), and an increased risk of death in elderly patients with dementia-related psychosis [2]. Common side effects may include weight gain, insomnia, and akathisia (a feeling of restlessness) [5].
How Does Rexulti Compare to Other Antipsychotics?
Brexpiprazole is considered an atypical antipsychotic, similar to other medications like aripiprazole (Abilify) and cariprazine (Vraylar), which also target dopamine and serotonin receptors [5][6]. While they share mechanisms of action, they differ in their receptor binding profiles and thus may have different efficacy and side effect profiles for individual patients [5][6].
What is the Price of Rexulti?
The cost of Rexulti can vary depending on insurance coverage, pharmacy, and dosage [7]. As a branded medication, it is typically more expensive than its future generic equivalent would be [7].
Sources
1. DrugPatentWatch.com
2. U.S. Food and Drug Administration (FDA)
3. United States Patent and Trademark Office (USPTO)
4. Otsuka Pharmaceutical Co., Ltd.
5. National Institutes of Health (NIH) - MedlinePlus
6. Vraylar (cariprazine) prescribing information
7. GoodRx