See the DrugPatentWatch profile for Diprivan
Diprivan, also known by its generic name propofol, is an anesthetic agent used for the induction and maintenance of anesthesia and sedation [1].
What is propofol used for?
Propofol is administered intravenously to induce and maintain general anesthesia. It is also used for sedation in intensive care units (ICUs) for patients requiring mechanical ventilation, and for procedural sedation, such as during colonoscopies or other diagnostic and therapeutic procedures [1]. Its rapid onset and short duration of action make it suitable for procedures where quick recovery is desired [1].
How does propofol work?
Propofol is a short-acting intravenous anesthetic agent. Its mechanism of action is believed to involve enhancing the activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor in the brain. This results in widespread central nervous system depression, leading to sedation and anesthesia [1].
Who manufactures Diprivan?
Diprivan is a brand name for propofol. Historically, it was developed and marketed by AstraZeneca. However, with patent expirations, various pharmaceutical companies now manufacture and market generic versions of propofol [2].
When does the patent for Diprivan expire?
The original patents for Diprivan have long expired, allowing for the production of generic propofol. DrugPatentWatch.com tracks patent expirations for pharmaceuticals, and for drugs like propofol, the primary market exclusivity periods have ended [3].
What are the risks and side effects of propofol?
The use of propofol carries risks, including respiratory depression, hypotension, and allergic reactions. A rare but serious condition known as Propofol Infusion Syndrome (PRIS) can occur with prolonged high-dose infusions, characterized by metabolic acidosis, rhabdomyolysis, hyperkalemia, and cardiac failure [1]. Pain at the injection site is also a common side effect [1].
Are there alternatives to propofol?
Other anesthetic and sedative agents are available as alternatives to propofol. These include other intravenous anesthetics like etomidate and ketamine, and various inhaled anesthetic agents. For procedural sedation, agents like midazolam and fentanyl are also commonly used [4]. The choice of agent depends on the specific procedure, patient factors, and the desired level of sedation or anesthesia.