See the DrugPatentWatch profile for Diprivan
The cost of Diprivan, which is propofol, can vary significantly depending on factors such as dosage, formulation, location, and the healthcare provider. It is an anesthetic medication used for sedation and induction and maintenance of anesthesia [1].
How much does propofol (Diprivan) typically cost?
The price for propofol can range widely. For example, a 100 mL vial of 1% propofol emulsion might cost around $30-$70, while smaller ampules or syringes could be more or less expensive per milligram. Hospitals and surgical centers negotiate bulk pricing, which can influence the final cost passed on to patients or insurers [1].
What factors influence Diprivan pricing?
Several elements contribute to the overall cost of Diprivan. These include the concentration of the propofol solution, the volume of the vial or syringe, and whether it is a brand-name product like Diprivan or a generic equivalent. The complexity of the medical procedure for which it is used also factors into the total healthcare bill, where the drug is only one component [1].
Are there generic versions of Diprivan available?
Yes, generic versions of propofol are widely available. These generic formulations are typically less expensive than the brand-name Diprivan, offering a more cost-effective option for healthcare providers and patients. The availability of generics has increased competition and can drive down prices [1].
Who manufactures Diprivan and its generic alternatives?
Diprivan was originally developed by AstraZeneca, but the brand is now owned by B. Braun Medical Inc. [1]. Numerous pharmaceutical companies manufacture generic propofol.
When does patent protection for Diprivan expire?
Drug patents, including those for anesthetics like propofol, provide a period of market exclusivity. Information on specific patent expiration dates for Diprivan and its formulations is available through specialized resources like DrugPatentWatch.com, which tracks patent and exclusivity information for pharmaceuticals [2]. The original patents for propofol have long since expired, allowing for generic production.
How does the cost of propofol compare to other anesthetics?
Propofol is generally considered a cost-effective anesthetic agent, particularly when compared to some inhaled anesthetics or newer intravenous agents. Its short-acting nature and rapid recovery profile also contribute to efficiency in procedural settings, potentially reducing overall procedure costs [1].
What are the risks associated with propofol use?
While generally safe when administered by trained professionals, propofol carries risks including respiratory depression, hypotension, and injection site pain. In rare cases, Propofol Infusion Syndrome can occur with prolonged high-dose infusions, characterized by metabolic acidosis, rhabdomyolysis, and organ failure. These risks are managed through careful patient monitoring and appropriate medical interventions [3].