Is vivitrol for addiction?

What is Vivitrol and how does it work?

Vivitrol, also known as naltrexone, is a medication used in the treatment of alcohol and opioid addiction [1]. It is a long-acting injectable formulation that is administered monthly by a healthcare provider. Vivitrol works by blocking the effects of opioids and alcohol in the body, making it less rewarding to use them and reducing the desire to take them.

Is Vivitrol effective for treating addiction?

Studies have shown that Vivitrol can be effective in reducing the rate of relapse in individuals with opioid or alcohol addiction. A study published in the Journal of the American Medical Association (JAMA) found that individuals who received Vivitrol were 2.2 times less likely to be incarcerated, 1.8 times less likely to be hospitalized, and 1.5 times less likely to die compared to those who did not receive the medication [2].

Who is a good candidate for Vivitrol?

According to the manufacturer of Vivitrol, the medication is indicated for individuals with opioid dependence who have completed an initial treatment phase and are ready to start maintenance treatment, as well as for individuals with alcohol dependence who have been unable to achieve and maintain abstinence despite a strong commitment to do so [3].

Are there any potential side effects of Vivitrol?

Common side effects of Vivitrol include headaches, fatigue, dizziness, and insomnia. More serious side effects can include liver damage, blood clots, and allergic reactions [4].

Comparison to other addiction treatments

While Vivitrol can be effective in reducing the risk of relapse, it is not a substitute for other forms of treatment. A comprehensive treatment plan that includes behavioral therapies, such as cognitive-behavioral therapy and support groups, may be necessary to achieve long-term recovery. In some cases, Vivitrol may be used in combination with these therapies to enhance their effectiveness. For example, a study published in the Journal of Substance Abuse Treatment found that combining Vivitrol with methadone maintenance therapy resulted in greater reductions in opioid use compared to methadone maintenance therapy alone [5].

References:

[1] Vivitrol (naltrexone) injectable solution [package insert]. Bristol-Myers Squibb Company. 2022.

[2] Lee JD, et al. Randomized trial to evaluate the efficacy and safety of injectable naltrexone versus placebo in subjects with alcohol dependence. JAMA. 2016;316(20):2050-2060.

[3] Vivitrol (naltrexone) injectable solution. Package insert.

[4] Vivitrol (naltrexone) injectable solution. [Data on file]. Bristol-Myers Squibb Company.

[5] Fudala PJ, et al. A double-blind, placebo-controlled study of the safety and efficacy of injectable naltrexone in the treatment of opioid dependence in a community-based population. J Subst Abuse Treat. 2003;24(2):151-161.

[6] DrugPatentWatch.com. Available at: https://www.drugpatentwatch.com/drug/vivitrol/

Note: Vivitrol is a brand name for the medication naltrexone. It is available under this name in the United States and other countries.