Standard Adult Dosing for Amoxicillin
Amoxicillin dosing varies by infection type and severity. Typical oral doses for adults (over 40 kg) are 250-500 mg every 8 hours or 500-875 mg every 12 hours, taken for 7-14 days depending on the condition. For severe infections like pneumonia, up to 1 gram every 8 hours may be used.[1][2]
Common Uses and Specific Doses
- Ear, nose, throat, or skin infections: 250 mg every 8 hours or 500 mg every 12 hours.
- Lower respiratory tract infections: 875 mg every 12 hours.
- Urinary tract infections: 500 mg every 12 hours.
- Helicobacter pylori eradication (with other drugs): 1 gram every 12 hours for 7-14 days.
- Gonorrhea (single dose): 3 grams, often with probenecid.[1][2]
Pediatric Dosing
For children under 40 kg, base on weight: 20-90 mg/kg/day divided every 8-12 hours. Maximum daily dose is usually 4 grams. For acute otitis media, 80-90 mg/kg/day in divided doses.[1][2]
How Long to Take It
Courses last 5-14 days; finish the full prescription even if symptoms improve to prevent resistance.[1]
Adjustments for Kidney Issues
Reduce dose in renal impairment: For creatinine clearance 10-30 mL/min, give 250-500 mg every 12 hours; below 10 mL/min, every 24 hours.[1][2]
What If I Miss a Dose?
Take it as soon as possible unless near the next dose; do not double up.[1]
Side Effects Patients Report Most
Common: nausea, diarrhea, rash. Rare but serious: allergic reactions (hives, swelling), Clostridium difficile diarrhea. Stop and seek help for severe symptoms.[1][2]
Amoxicillin vs. Amoxicillin-Clavulanate (Augmentin)
Plain amoxicillin treats susceptible bacteria; Augmentin adds clavulanate for beta-lactamase producers, with similar dosing but higher diarrhea risk.[2]
Overdose Risks
Symptoms include nausea, vomiting, stomach pain. Seek emergency care; activated charcoal may help if recent.[1]
Sources
[1]: Drugs.com - Amoxicillin Dosage
[2]: Medscape - Amoxicillin Dosing