Trazodone is sold under several brand names. The most common U.S. brand name for trazodone is Desyrel [1]. Other commercial names under which trazodone has been marketed include Oleptro [2].
Is Trazodone Available as a Generic?
Trazodone is available as a generic medication [3]. This means that in addition to branded versions, it can be manufactured and sold by multiple pharmaceutical companies under its generic name, trazodone hydrochloride.
What Conditions Does Trazodone Treat?
Trazodone is primarily prescribed for the treatment of major depressive disorder [4]. It is also frequently used off-label to treat insomnia, particularly in patients with depression who experience sleep disturbances [5].
How Does Trazodone Work?
Trazodone is classified as a serotonin antagonist and reuptake inhibitor (SARI) [6]. It works by affecting serotonin levels in the brain, which can help to improve mood and sleep [4][6]. Its mechanism of action involves blocking certain serotonin receptors and inhibiting the reuptake of serotonin, leading to increased availability of this neurotransmitter in the synaptic cleft [6].
What Are Common Side Effects of Trazodone?
Common side effects associated with trazodone use include drowsiness, dizziness, dry mouth, blurred vision, and constipation [7]. Less common but serious side effects can include priapism, a prolonged and painful erection, and orthostatic hypotension, a drop in blood pressure upon standing [8][9]. Patients are advised to report any persistent or concerning side effects to their healthcare provider [7].