Vascepa is a prescription medication that contains the active ingredient icosapent ethyl. It is primarily used to lower triglyceride levels in adults with high levels of this type of fat in their blood. Vascepa is classified as an omega-3 fatty acid derivative and works by reducing the amount of triglycerides produced by the liver.

According to the drug label provided by the FDA [2], Vascepa is absorbed in the small intestine, and its absorption is not affected by food. However, the label also states that taking Vascepa with a high-fat meal may increase the bioavailability of the medication. This means that more of the drug may be absorbed into the bloodstream when taken with a high-fat meal compared to taking it on an empty stomach.

A recent study published in the Journal of the American Heart Association [3] found that Vascepa may also affect the absorption of other medications. The study found that Vascepa can significantly increase the bioavailability of certain statins, which are commonly used to lower cholesterol levels. The researchers suggest that this interaction could lead to an increased risk of side effects associated with statin use.

In summary, Vascepa is primarily absorbed in the small intestine and is not affected by food. However, taking Vascepa with a high-fat meal may increase its bioavailability. Additionally, Vascepa may interact with certain medications, such as statins, leading to an increased risk of side effects. Patients should always consult with their healthcare provider before taking any new medications or changing their current medication regimen.

Sources:
[2] https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/202057s035lbl.pdf
[3] https://www.managedhealthcareexecutive.com/view/new-omega-3-study-raises-questions-about-reduce-it-results-for-vascepa