Leucovorin calcium cost?

Leucovorin calcium is a vitamin B 10 (folinic acid) used mainly to “rescue” normal cells from the toxic effects of methotrexate or as a supplement in certain chemotherapies and other indications. Because it’s sold in several different strengths and routes, the price can vary widely depending on:

| Formulation | Typical US retail cost (approx.) | Notes |
|-------------|----------------------------------|-------|
| Oral tablets (25 mg) | $2–$6 per tablet | Most inexpensive; often covered by insurance. |
| Oral tablets (100 mg) | $5–$10 per tablet | Less common, but still inexpensive. |
| Injection (5 mg/mL vial) | $10–$25 per vial | Used in oncology and other inpatient settings. |
| Injection (20 mg/mL vial) | $15–$35 per vial | Higher concentration, less volume per vial. |
| Compounded preparations | $20–$40 per vial (price varies) | Some compounding pharmacies offer lower‑cost options. |

Factors that influence the final cost

1. Insurance coverage – Many plans cover leucovorin, often at a lower co‑pay or with a higher deductible.
2. Manufacturer – Brand‑name vs. generic. Generic forms are usually cheaper.
3. Dosage and duration – The more frequent the dosing, the higher the total cost.
4. Geography – Prices can differ by state or pharmacy chain.
5. Bulk purchasing or hospital formulary – Hospitals may negotiate lower prices for larger orders.

How to get the most accurate price

- Ask your pharmacist – They can check the current price at your local pharmacy and confirm whether it’s covered by your plan.
- Use online prescription discount cards – Sites like GoodRx can show you the lowest available price in your area.
- Check with your insurance – Call the member services number or log into your portal to see if leucovorin is in your formulary and what the out‑of‑pocket cost will be.

Quick tip
If you’re receiving leucovorin as a “chemo‑rescue” during methotrexate therapy, many hospitals provide the drug at a very low cost (often under $5 per vial) because it’s part of the standard care protocol. If you’re buying it over the counter for a different purpose, the tablet form will be your cheapest option.

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If you have a specific dosage or route in mind, let me know and I can give you a more precise estimate for that form.