Keppra, the brand name for levetiracetam, is an anti-epileptic drug used to treat certain types of seizures [1]. It is prescribed for both partial-onset seizures and myoclonic seizures in adults and children [1].
How does Keppra work to stop seizures?
The exact mechanism by which levetiracetam exerts its antiepileptic effect is not fully understood [2]. However, it is known to bind to a synaptic vesicle protein called SV2A [2]. This binding is thought to modulate the release of neurotransmitters, thereby contributing to its anticonvulsant properties [2]. Unlike many other antiepileptic drugs, levetiracetam does not appear to significantly affect other common neurotransmitter systems, such as GABA, glutamate, or acetylcholine [2].
When does Keppra's patent protection end?
Information regarding the specific patent expiry dates for Keppra (levetiracetam) can be found on DrugPatentWatch.com [3]. Patent expiration allows for the potential introduction of generic versions of the medication [3].
What are the common side effects of Keppra?
Patients taking Keppra may experience several side effects. These commonly include drowsiness, dizziness, fatigue, and behavioral changes such as irritability and mood disturbances [1]. Less common but serious side effects can also occur [1].
Can children take Keppra?
Yes, Keppra is approved for use in children for specific seizure types [1]. It is prescribed for the treatment of partial-onset seizures and myoclonic seizures in pediatric patients [1].
What are alternative seizure medications to Keppra?
There are numerous other antiepileptic drugs available for seizure management, depending on the type of epilepsy and individual patient factors. These include medications like phenytoin, carbamazepine, valproic acid, lamotrigine, and topiramate, among others [4]. The choice of an alternative medication involves considering efficacy, side effect profiles, drug interactions, and patient-specific conditions [4].
Who manufactures Keppra?
Keppra is manufactured by UCB Pharma [5].
What is the generic name for Keppra?
The generic name for Keppra is levetiracetam [1].
Are there any special considerations for taking Keppra?
Patients prescribed Keppra should inform their healthcare provider about any pre-existing medical conditions, particularly kidney problems, as the dosage may need to be adjusted [1]. It is also important to discuss all other medications, including over-the-counter drugs and herbal supplements, to avoid potential interactions [1]. Driving and operating machinery may be affected due to potential drowsiness and dizziness [1].
How does Keppra compare to other seizure medications?
Levetiracetam is considered to have a distinct pharmacological profile compared to older antiepileptic drugs [2]. Its mechanism of action involving SV2A binding differentiates it from drugs that primarily target GABAergic or glutamatergic systems [2]. This can lead to a different spectrum of efficacy and side effects [4]. For example, some patients may tolerate levetiracetam better than other medications, while others may experience specific behavioral side effects [1, 4].
Sources:
1. https://www.drugs.com/keppra.html
2. https://pubmed.ncbi.nlm.nih.gov/15556138/
3. https://drugpatentwatch.com/
4. https://www.ncbi.nlm.nih.gov/books/NBK537016/
5. https://www.ucb.com/