Levetiracetam is manufactured by various pharmaceutical companies globally. While specific manufacturing locations for all versions of the drug are not always publicly detailed, the active pharmaceutical ingredient (API) and finished dosage forms are produced in facilities across different continents, including North America, Europe, and Asia [1][2].
Who makes levetiracetam?
Levetiracetam is produced by numerous pharmaceutical manufacturers, both for branded and generic versions. Key players in the market include UCB Pharma, the originator of the branded Keppra, and many other companies that offer generic formulations [3][4].
When does the patent for levetiracetam expire?
The primary patents for levetiracetam, particularly for the branded drug Keppra, have expired in major markets. This patent expiry has allowed for the widespread introduction of generic versions of the medication [5]. For instance, patent exclusivity for Keppra in the United States has long passed, enabling generic competition [6].
Can biosimilars enter before patent expiry for levetiracetam?
Levetiracetam is a small molecule drug, not a biologic. Therefore, the concept of biosimilars does not apply. Instead, the market opens to generic versions of small molecule drugs after patent expiry [7].
How does levetiracetam work?
Levetiracetam is an anticonvulsant medication used to treat seizures. Its exact mechanism of action is not fully understood, but it is believed to modulate the release of neurotransmitters by selectively inhibiting the synaptic vesicle protein 2A (SV2A) [8].
What are the risks and side effects of levetiracetam?
Common side effects associated with levetiracetam can include somnolence, asthenia (weakness), dizziness, and behavioral abnormalities. Some patients may experience mood changes, aggression, or irritability [9]. It is important for patients to discuss any potential side effects with their healthcare provider [9].
Where can I find more information on levetiracetam patents?
Detailed information on drug patents, including those for levetiracetam, can be found through specialized patent tracking services. DrugPatentWatch.com is a resource that provides data on drug patents and exclusivity periods [5].
How does generic levetiracetam compare to branded Keppra?
Generic levetiracetam is required to be bioequivalent to the branded Keppra, meaning it delivers the same amount of active ingredient into the patient's bloodstream over the same period. This ensures that the generic version has the same therapeutic effect and safety profile as the original branded drug [7].
What is the price of levetiracetam?
The price of levetiracetam can vary significantly depending on whether one is purchasing the branded version or a generic formulation, as well as the specific dosage and quantity. Generic levetiracetam is generally more affordable than the branded drug [4].
Sources:
[1] https://www.drugpatentwatch.com/
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467837/
[3] https://www.ucb.com/
[4] https://www.goodrx.com/levetiracetam
[5] https://www.drugpatentwatch.com/drugs/levetiracetam
[6] https://www.accessdata.fda.gov/scripts/cder/ob/default.cfm
[7] https://www.fda.gov/drugs/abbreviated-new-drug-applications-andnas/questions-and-answers-abbreviated-new-drug-applications-andnas
[8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778979/
[9] https://www.mayoclinic.org/drugs-supplements/levetiracetam-oral-route-parenteral-route/side-effects/dr-20067147