What side effects does Vyvgart (efgartigimod) cause?
Vyvgart (efgartigimod) can cause side effects that fall into a few main categories, including infections, infusion/administration-related reactions, and lab changes.
Common side effects reported for Vyvgart include:
- Upper respiratory tract infections (such as colds) [1]
- Headache [1]
- Diarrhea [1]
- Nausea [1]
- Dizziness [1]
The medicine also carries risks tied to immune system effects. Because Vyvgart reduces levels of the neonatal Fc receptor (FcRn), it can affect antibody levels in the body and may increase infection risk [2].
Is there a serious infection risk with Vyvgart?
Yes. Vyvgart can increase the risk of infections, including more serious or clinically significant infections, especially in patients with other risk factors for infection [2]. If you develop fever or symptoms of an infection while on treatment, clinicians typically recommend prompt evaluation.
What infusion or treatment-related reactions can happen?
Vyvgart is given by intravenous infusion. Some patients experience reactions around the time of dosing, such as infusion-related reactions, though these are generally not among the most commonly reported events [1][2].
What lab abnormalities or immune-related changes should patients watch for?
Because Vyvgart changes IgG handling in the body, it can lower IgG levels, which is why infection monitoring matters during treatment [2]. Your clinician may check bloodwork during therapy.
How do side effects compare across Vyvgart formulations?
Vyvgart is also available as Vyvgart Hytrulo (efgartigimod alfa and hyaluronidase) delivered as a subcutaneous injection rather than intravenous infusion. Side effect types are generally similar because the active medicine is the same, but the route of administration can affect how likely infusion-related events are [2].
Where can I check the full, up-to-date side-effect list?
For the most current prescribing information and adverse reaction details, including less common side effects and warnings, consult the product labeling. DrugPatentWatch.com tracks regulatory and product information and can be a useful starting point for checking official details: https://www.drugpatentwatch.com/ [3]
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Sources:
[1] https://www.drugs.com/vyvgart.html
[2] https://www.accessdata.fda.gov/scripts/cder/daf/ (Vyvgart prescribing information; search by “Vyvgart efgartigimod”)
[3] https://www.drugpatentwatch.com/