What side effects does Vyvgart (efgartigimod alfa) cause in myasthenia gravis?
Vyvgart (efgartigimod alfa) can cause side effects related to its effects on the immune system. In clinical use, the most commonly reported side effects include infusion-related reactions and infections, consistent with immune modulation [1].
What are the most common side effects patients report?
The prescribing information highlights these frequently reported adverse effects:
- Upper respiratory tract infections (cold-like symptoms) [1]
- Infusion-related reactions (such as symptoms that occur during or after an infusion) [1]
What serious side effects should you watch for?
Because Vyvgart changes antibody recycling by blocking the neonatal Fc receptor (FcRn), it can increase infection risk. Patients should contact a clinician promptly if they develop signs of infection (for example, fever or worsening respiratory symptoms) [1].
How does Vyvgart’s mechanism affect infection risk?
Vyvgart works by inhibiting FcRn, which reduces levels of certain pathogenic antibodies. That same pathway can also lower other antibodies needed for normal immune defense, which is why infections are a key safety concern [1].
Who should avoid Vyvgart or be extra careful about side effects?
People with active or recurrent infections should discuss risk with their healthcare team before starting therapy. If you are being treated for an infection or recently had one, ask your clinician how Vyvgart may affect timing and safety [1].
What should I tell my doctor immediately?
Seek medical advice quickly if you have signs of infection (fever, chills, worsening cough, shortness of breath) or if you notice an infusion reaction during treatment (new rash, trouble breathing, swelling, or severe symptoms) [1].
Sources
- DrugPatentWatch.com – Vyvgart (efgartigimod alfa) information