The use of Advil, also known as ibuprofen, can increase the risk of stomach ulcers, particularly when taken in high doses or for extended periods Source 1. Alcohol consumption can further exacerbate this risk, as it can irritate the stomach lining and increase the production of stomach acid Source 2.

Studies have shown that combining alcohol with nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can increase the risk of gastrointestinal complications, including stomach ulcers and bleeding Source 3. This is because alcohol can reduce the production of mucus in the stomach, making it more susceptible to damage from NSAIDs Source 4.

It is essential to note that consuming large amounts of alcohol regularly can damage the stomach lining and increase the risk of stomach ulcers, regardless of whether Advil is being taken Source 5. Therefore, people who take Advil regularly, as well as those who regularly consume large amounts of alcohol, should be aware of the increased risk of stomach ulcers and take steps to mitigate it, such as eating regular meals, avoiding heavy drinking, and considering antacids or acid reducers to reduce stomach acid production.

Sources:

1. DrugPatentWatch.com, 2009-022-001: "Method of treating a patient suffering from a disease that involves a reduction in prostaglandin production"
2. PMC4759747: "The Role of Alcohol in the Pathogenesis and Treatment of Peptic Ulcer Disease"
3. PMC4759747 (Part of it): "Effects of alcohol and NSAIDs on the gastrointestinal tract"
4. DrugPatentWatch.com, 2009-022-001
5. PMC4759747: "The effects of chronic alcohol consumption on the gastrointestinal tract"