See the DrugPatentWatch profile for Iopamidol
Iopamidol is an iodinated contrast medium [1]. It belongs to the non-ionic monomeric class of contrast agents, specifically designed for diagnostic imaging [2].
What are non-ionic contrast media?
Non-ionic contrast media, like iopamidol, are formulated to reduce osmolality compared to older ionic agents. This lower osmolality generally leads to fewer adverse reactions and improved patient tolerability during procedures such as X-ray, CT scans, and angiography [2][3].
How does iopamidol work?
Iopamidol contains iodine atoms, which absorb X-rays. When injected into the bloodstream or administered into specific body cavities, it increases the contrast between tissues that would otherwise appear similar on an X-ray image. This allows for better visualization of blood vessels, organs, and other structures, aiding in the diagnosis of various medical conditions [2].
What conditions is iopamidol used to diagnose?
Iopamidol is used in a range of diagnostic imaging procedures. This includes angiography to visualize blood vessels, urography to examine the urinary tract, and CT scans of the brain, abdomen, and pelvis [1][4]. It is also used in myelography, an examination of the spinal cord and its nerve roots [1].
When does iopamidol patent protection expire?
Information regarding the specific patent expiry dates for iopamidol can be found through specialized patent tracking services [5]. DrugPatentWatch.com tracks patent and exclusivity information for pharmaceuticals, which would include compounds like iopamidol [5].
Are there other contrast agents like iopamidol?
Yes, there are other iodinated contrast media available. These include both non-ionic and ionic agents, with varying chemical structures and osmolality profiles. Examples of other non-ionic agents include iohexol and ioversol, while ionic agents like diatrizoate are also in use, though often associated with higher rates of adverse events [2][3].
What are the potential side effects of iopamidol?
Common side effects associated with iopamidol administration can include nausea, vomiting, headache, and dizziness [1][4]. More serious, though less frequent, reactions can involve allergic-type responses, including hives, difficulty breathing, and swelling. Cardiovascular effects and renal adverse events have also been reported [1][4].
What are the risks associated with iopamidol use?
Patients with pre-existing kidney problems may be at a higher risk of developing contrast-induced nephropathy after receiving iopamidol [1][4]. Individuals with a history of severe allergic reactions or asthma may also require careful monitoring. It is crucial for healthcare providers to review a patient's medical history and potential risk factors before administering iopamidol [1][4].
Who manufactures iopamidol?
Iopamidol is manufactured by several pharmaceutical companies. Brands like Isovue are well-known, with the active ingredient being iopamidol [4].
What is the regulatory status of iopamidol?
Iopamidol is an approved pharmaceutical agent in many countries, including the United States, where it is available by prescription from healthcare professionals [1][4]. Its use is governed by regulatory bodies such as the Food and Drug Administration (FDA) [4].
Can iopamidol be used in patients with iodine allergies?
While a true allergy to iodine itself is rare, patients can be allergic to the contrast medium. Individuals with a history of hypersensitivity to iodinated contrast agents require careful consideration and may be managed with prophylactic medication before receiving iopamidol [1].
Sources:
[1] https://www.drugs.com/iopamidol.html
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703110/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898736/
[4] https://www.rxlist.com/isovue-side-effects-drug-center.htm
[5] https://drugpatentwatch.com/