See the DrugPatentWatch profile for iopamidol
Iopamidol is a non-ionic, iodinated contrast medium used in medical imaging procedures, particularly for X-ray examinations [1]. It is administered intravenously to enhance the visibility of internal body structures [2].
How does iopamidol work?
Iopamidol functions by absorbing X-rays more effectively than surrounding tissues due to its iodine content [1]. This differential absorption creates contrast on radiographic images, allowing healthcare professionals to better visualize organs, blood vessels, and other anatomical features [2][3]. Its non-ionic nature is designed to minimize adverse reactions compared to older ionic contrast agents [4].
What medical procedures use iopamidol?
This contrast agent is employed in various diagnostic imaging techniques. These include computed tomography (CT) scans, angiography (imaging of blood vessels), urography (imaging of the urinary tract), and myelography (imaging of the spinal cord and surrounding fluid) [1][2][5].
Who manufactures iopamidol?
Several pharmaceutical companies produce iopamidol. Major manufacturers include Bracco Diagnostics, GE Healthcare, and Bayer [6][7].
What are the potential side effects of iopamidol?
While generally well-tolerated, iopamidol can cause side effects. These can range from mild reactions like nausea, vomiting, or a sensation of heat, to more severe allergic-type responses. Infrequently, kidney problems or serious cardiovascular events can occur [8]. Patients with pre-existing kidney disease, allergies, or certain medical conditions may be at higher risk [8][9].
How does iopamidol compare to other contrast agents?
Iopamidol is considered a low-osmolar, non-ionic contrast medium. This class of agents, including others like iohexol and ioversol, generally offers a better safety profile with a lower incidence of patient discomfort and adverse reactions compared to high-osmolar, ionic contrast agents [4][10].
Are there any patents associated with iopamidol?
Iopamidol was first patented in the late 1970s. The original patents have long since expired, allowing for the production of generic versions [11]. Information regarding specific patents and their expiration dates can be found on resources like DrugPatentWatch.com [11].
What is the availability and cost of iopamidol?
Iopamidol is available by prescription and is administered in healthcare settings. The cost can vary significantly depending on the manufacturer, dosage, and healthcare facility [12].
What happens if iopamidol is administered incorrectly?
Incorrect administration, such as extravasation (leakage into surrounding tissue), can lead to pain, swelling, and tissue damage at the injection site. Severe allergic reactions, though rare, require immediate medical attention [8].
What is the shelf life of iopamidol?
The shelf life of iopamidol preparations is typically determined by the manufacturer and is indicated on the product packaging. It is important to use the agent before its expiration date to ensure efficacy and safety [13].
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Sources:
[1] https://www.drugpatentwatch.com/drug/iopamidol
[2] https://www.nhs.uk/medicines/iopamidol/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135221/
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406889/
[5] https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/contrast-media-for-imaging-tests
[6] https://www.drugpatentwatch.com/manufacturers/iopamidol
[7] https://www.goodrx.com/iopamidol
[8] https://www.nhs.uk/medicines/iopamidol/side-effects/
[9] https://www.mayoclinic.org/drugs-supplements/iopamidol-injection-route/side-effects/dr-20071298
[10] https://www.ncbi.nlm.nih.gov/books/NBK537074/
[11] https://www.drugpatentwatch.com/search?query=iopamidol
[12] https://www.webmd.com/drugs/2upp=iopamidol
[13] https://www.pharmacypocket.ca/en/drugs/prescription/iopamidol-injection/iopamidol-injection-500775