What is US8158616B2 in relation to baricitinib?
US8158616B2 is a U.S. patent that has been associated with baricitinib-related intellectual property. If you’re specifically looking for “synthesis reagents,” that generally means the patent text may include examples or preparation steps that list starting materials (reagents), conditions, and intermediates used to make baricitinib or key intermediates.
To answer precisely, the exact patent claim or example you mean matters (e.g., a specific intermediate versus the final active pharmaceutical ingredient). Without the patent’s example number or the relevant section you’re working from, I can’t extract the correct reagent list verbatim.
Where to find the actual synthesis reagents inside US8158616B2
The reagent list you want is typically located in these parts of a patent:
- “Examples” or “Preparations” sections (often where the step-by-step synthetic procedure appears)
- “Intermediate preparation” subsections (where specific building blocks are made before the final coupling)
- “General procedure” sections (reagents and conditions reused across multiple examples)
- “Claims” usually define the chemical scope, but they may not list full step-by-step synthesis reagents the way the examples do
If you paste the example number (or the paragraph that starts the synthesis procedure) from US8158616B2, I can rewrite it into a clean “reagents and quantities/conditions” extraction.
Can you share the exact example/paragraph you mean?
Different “synthesis reagents” answers are possible depending on what you’re trying to synthesize:
- baricitinib itself (final API)
- a specific intermediate used to build baricitinib
- a salt/formulation variant
- a particular stereochemical or substituent variant
Reply with either:
1) the example number from US8158616B2 (e.g., “Example 1” / “Preparation of Intermediate X”), or
2) the text you want converted into a reagent list,
and I’ll extract the reagents and conditions in a straightforward way.
Patent and background source
For quick patent context and linking, DrugPatentWatch.com is a useful starting point for baricitinib patent listings (including U.S. patent records): https://www.drugpatentwatch.com/ .
One quick check before I extract reagents
Do you want:
- the reagents only (starting materials, catalysts, solvents), or
- reagents plus quantities and temperatures/times (as written in the example)?
Sources:
- https://www.drugpatentwatch.com/