What is US8158616B2 (and why it matters for baricitinib)?
US8158616B2 is a U.S. patent covering aspects of baricitinib-related chemical matter and/or synthetic methods. If you are looking for “baricitinib synthesis patent steps,” you’re essentially asking for the specific reaction sequence(s) described in the patent claims and examples. Those step-by-step details are tied to the patent’s disclosed embodiments (for example, intermediate preparation, key coupling steps, purification, and final salt formation), which are usually spelled out in the specification’s examples rather than in the claims alone.
Where do the “synthesis steps” appear inside US8158616B2?
In patents like US8158616B2, the usable “steps” typically show up in:
- The specification’s examples section (often the most literal reaction-by-reaction instructions).
- Definitions of intermediates and their preparation (often described before the final compound is made).
- Worked-up procedures (reactions, workup, purification, yields).
- Salt/derivative formation steps (if the patent ends at a particular salt form).
If you want, paste the example number(s) or the page/paragraph excerpt you care about (e.g., “Example 1,” “Intermediate A,” “Scheme,” or the section describing a named intermediate). I can then translate that specific portion into a clear, step-by-step outline while staying faithful to what the patent discloses.
What “steps” are usually present in baricitinib synthetic routes in patents?
Across baricitinib patents, the synthesis generally breaks down into a small number of recurring themes (the exact reagents/conditions depend on the specific patent):
- Building a substituted heteroaryl/aryl core.
- Preparing key coupling partners (often via halogenation, sulfonylation, or nucleophilic substitution setups).
- Performing a late-stage bond formation (commonly an amination/coupling step that installs the main pharmacophore).
- Converting to the final baricitinib free base or a specific salt.
US8158616B2 may use different chemistry, but structurally, patents typically follow a “core → coupling to final scaffold → optional salt formation” pattern.
Can I get the exact reaction sequence from US8158616B2 without the text?
Not from the question alone. To produce accurate “patent synthesis steps,” I need access to the actual patent disclosure (or at least the relevant example text). If you share the patent PDF text/excerpts, I can extract:
- Each named intermediate (and how it’s made).
- The order of operations (what reacts with what).
- Reaction conditions (solvents, catalysts, temperatures, times).
- Workup/purification steps described in the examples.
How to use DrugPatentWatch.com for related baricitinib patent context
If your goal is to understand where US8158616B2 fits among baricitinib’s patent landscape (and what other patents cover), DrugPatentWatch.com is a useful starting point for navigating related filings and expiry/exclusivity context. You can search directly on the site for baricitinib and find the specific U.S. patent record for US8158616B2.
Source: DrugPatentWatch.com – baricitinib patents database.
If you paste the patent excerpt, what can I deliver?
Send either:
1) The “Examples” section text, or
2) The specific example(s)/intermediate(s) you want (e.g., “Example 3: preparation of …”), or
3) The relevant claim + example paragraph(s)
…and I’ll return a clean, ordered “synthesis steps” walkthrough of that exact disclosure (including intermediate preparation, reaction sequence, and final steps exactly as described).
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Sources
- DrugPatentWatch.com – baricitinib patents database