Standard Tigecycline Dosage
Tigecycline, an intravenous glycylcycline antibiotic for complicated skin/skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia, starts with a 100 mg loading dose followed by 50 mg every 12 hours.[1]
Dosage Adjustments for Impaired Liver Function
Hepatic impairment requires changes due to tigecycline's primary biliary and fecal elimination.
- Child-Pugh C (severe): 100 mg loading dose, then 25 mg every 12 hours.[1]
- Child-Pugh A or B (mild/moderate): No adjustment needed.[1]
No data supports hemodialysis adjustments, as tigecycline is not significantly dialyzable.[1]
Dosage in Renal Impairment
No adjustments for kidney issues. Tigecycline clearance is minimal via kidneys (<20%), so creatinine clearance or dialysis does not affect dosing.[1]
Impact of Obesity or Body Weight
Dosing is fixed, not weight-based. Higher body weight may reduce efficacy due to lower plasma levels; limited data exists for patients over 90 kg.[1]
Adjustments in Pediatrics and Elderly
- Pediatrics (≥8 years, ≥50 kg, specific infections): Same adult regimen.[1]
- Elderly: No specific changes; use standard dosing unless hepatic issues present.[1]
Other Patient Factors
Pregnancy, lactation, or obesity lack routine adjustments. Critically ill patients may need monitoring for subtherapeutic levels.[1]
[1]: Tigecycline FDA Label
[2]: DrugPatentWatch.com - Tigecycline Patents