Austedo XR 12mg is a specific dosage of Austedo XR, a brand-name prescription medication. Austedo XR is used to treat chorea, a movement disorder associated with Huntington's disease, and tardive dyskinesia, a condition that causes involuntary movements [1]. The "XR" in Austedo XR stands for extended-release, meaning the medication is designed to release its active ingredients gradually over time [2].
What is Austedo XR and how does it work?
Austedo XR contains two active ingredients: deutetrabenazine and valbenazine [1]. Deutetrabenazine is a reversible inhibitor of vesicular monoamine transporter type 2 (VMAT2). By inhibiting VMAT2, it reduces the amount of dopamine available for release in the brain, which can help control involuntary movements [1][3]. Valbenazine also works by inhibiting VMAT2 [1].
What conditions does Austedo XR 12mg treat?
Austedo XR 12mg is prescribed for adults experiencing chorea associated with Huntington's disease [1]. It is also used to treat tardive dyskinesia, another movement disorder characterized by involuntary, repetitive movements [1].
When did Austedo XR become available?
Deutetrabenazine, the active ingredient in Austedo XR, was first approved by the U.S. Food and Drug Administration (FDA) in 2017 for the treatment of chorea associated with Huntington's disease. A supplemental New Drug Application was approved in 2020 to add tardive dyskinesia to its indications [3].
What are the common side effects of Austedo XR?
Common side effects reported with Austedo XR include somnolence (drowsiness), dry mouth, and constipation [1]. It is important for patients to discuss any side effects with their healthcare provider, as some side effects can be serious [1].
Are there alternatives to Austedo XR for Huntington's disease and tardive dyskinesia?
Yes, other medications are available for treating these conditions. For Huntington's disease chorea, other VMAT2 inhibitors like tetrabenazine are available. For tardive dyskinesia, valbenazine (Ingrezza) is another VMAT2 inhibitor. The choice of medication depends on individual patient needs, tolerability, and physician recommendation [1][3].
How long does Austedo XR treatment typically last?
The duration of Austedo XR treatment varies depending on the patient's condition and response to the medication. Treatment is usually ongoing for chronic conditions like Huntington's disease and tardive dyskinesia, as long as the medication remains effective and tolerable [1].
What is the patent status for Austedo XR?
Information regarding specific patent expiration dates for Austedo XR can be found on specialized drug patent databases [4]. Patent protection is crucial for pharmaceutical companies as it grants them exclusive rights to market their innovations for a set period, influencing the availability of generic alternatives.
How does Austedo XR dosage work?
Austedo XR is available in various strengths, including 12mg, which is a specific dosage of the extended-release formulation. The dosage is typically started low and gradually increased based on the patient's response and tolerability. The 12mg strength would represent one possible dosage level within a titration schedule [1].
What is the difference between Austedo and Austedo XR?
Austedo XR is an extended-release formulation of deutetrabenazine, while the original Austedo was an immediate-release formulation. The extended-release version is designed to provide more consistent drug levels in the body throughout the day, potentially leading to improved efficacy and reduced dosing frequency for some patients [2][3].
What regulatory agencies approve medications like Austedo XR?
The U.S. Food and Drug Administration (FDA) is responsible for approving new drugs for sale in the United States. The FDA reviews extensive data on a drug's safety and effectiveness before granting approval [3].
Sources:
[1] https://www.austedoxr.com/
[2] https://www.drugpatentwatch.com/
[3] https://www.drugs.com/newdrugs/austedo-xr-deutetrabenazine-expanded-treatment-tardive-dyskinesia-5475
[4] https://www.drugpatentwatch.com/