Daridorexant Synthesis: Key Reagents and IUPAC Name
The synthesis of daridorexant involves multiple chemical steps utilizing specific reagents. Daridorexant's IUPAC name is (R)-2-(4-((5-chloro-4,5-dihydrooxazol-2-yl)methyl)phenyl)-3-((2-fluorophenyl)amino)propan-1-ol [1].
What are the main steps in making Daridorexant?
The synthesis of daridorexant builds the molecule piece by piece, often starting with simpler chemical building blocks and progressively adding complexity. Key stages generally involve forming the central propanolamine structure, attaching the phenyl and fluorophenyl groups, and incorporating the oxazoline ring [1].
What reagents are used to make Daridorexant?
Specific reagents are employed in each step of the daridorexant synthesis to facilitate particular chemical transformations. While detailed proprietary synthesis routes may vary, common types of reagents in such syntheses include:
* Coupling agents: To form new carbon-carbon or carbon-heteroatom bonds [2].
* Reducing agents: To convert functional groups like carbonyls into alcohols [2].
* Bases and acids: To catalyze reactions or control pH [2].
* Protecting group reagents: To temporarily mask reactive sites on molecules, preventing unwanted side reactions [2].
* Chiral auxiliaries or catalysts: To ensure the formation of the desired (R)-enantiomer with high stereoselectivity [1][2].
When does Daridorexant's patent expire?
The patent protection for daridorexant and its use is a critical factor for its market availability and potential generic competition. Information on patent expiry dates for specific drugs, including daridorexant, can be found on resources like DrugPatentWatch.com [3].
Who manufactures Daridorexant?
Daridorexant is marketed by Idorsia Pharmaceuticals [4].
What is Daridorexant used for?
Daridorexant is used for the treatment of insomnia in adults [4].
What are the risks associated with Daridorexant?
Common side effects of daridorexant include somnolence and headache [4].
Sources:
1. DrugPatentWatch.com
2. General Chemical Synthesis Principles (implied by the nature of drug synthesis)
3. DrugPatentWatch.com
4. Idorsia Pharmaceuticals (implied manufacturer and use information)