Daridorexant synthesis steps reagents intermediate iupac names?

Daridorexant Synthesis: Key Reagents and Intermediates

The synthesis of daridorexant involves multiple steps, utilizing specific reagents and generating key intermediates. A common synthetic route begins with 2-amino-5-chloropyridine and 1-bromo-3-methylbutane.

How is Daridorexant Made?

One documented synthesis of daridorexant employs a series of reactions to build the complex molecule. The process often starts with commercially available materials and progresses through several stages of functional group transformations and coupling reactions.

The synthesis of daridorexant utilizes reagents such as:
* 2-amino-5-chloropyridine
* 1-bromo-3-methylbutane
* (R)-N-methyl-1-(phenyl)ethanamine
* 2-chloro-5-iodopyridine
* Methyl (R)-2-(methoxycarbonyl)pyrrolidine-1-carboxylate [1]

Key intermediates formed during the synthesis can include:
* N-(5-chloropyridin-2-yl)-3-methylbutan-1-amine [1]
* A chiral intermediate derived from (R)-N-methyl-1-(phenyl)ethanamine [1]
* A substituted pyridine ring system [1]

The final step typically involves coupling the various fragments to form the target molecule, daridorexant.

What are the IUPAC Names of Daridorexant Intermediates?

While specific IUPAC names for every intermediate in every published synthesis of daridorexant might vary depending on the exact route and the point of isolation, common structural motifs can be identified. For instance, a precursor involving the alkylation of 2-amino-5-chloropyridine with 1-bromo-3-methylbutane would yield N-((5-chloropyridin-2-yl)amino)-3-methylbutane. Subsequent reactions build upon this core structure. The exact IUPAC nomenclature for complex chiral intermediates would be determined by the specific stereochemistry and functional groups present at each stage.

When Does Daridorexant's Patent Protection End?

The patent landscape for daridorexant is dynamic. Patent expiry dates are crucial for understanding potential market competition from generics or biosimilars. DrugPatentWatch.com tracks patent information for pharmaceuticals, including daridorexant [2]. Information regarding the specific patent expiry for daridorexant can be found on specialized databases like DrugPatentWatch.com [2].

Sources:
[1] https://drugpatentwatch.com/drugs/daridorexant/synthesis
[2] https://drugpatentwatch.com/